製品の概要

  • 製品名Anti-NR2C2 antibody [H0107B]
    NR2C2 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [H0107B] to NR2C2
  • アプリケーション適用あり: IP, WB, ELISA, IHC-FoFrmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Baculovirus-expressed recombinant fragment:

    IQGSEPASGPLSVFTSLNKEKIVTDQQTGQ

    , corresponding to Internal sequence amino acids 23-52 of Human NR2C2

  • ポジティブ・コントロール
    • Rat testis primary and secondary spermatocytes, rat cerebellum, purkinje and granular cells.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファーPreservative: 0.1% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 特記事項(精製)Purified by ammonium sulfate fractionation.
  • ポリ/モノモノクローナル
  • クローン名H0107B
  • ミエローマNS1
  • アイソタイプIgG2a
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab41954 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IP
WB
ELISA
IHC-FoFr
  • 追加情報ELISA: Use at a concentration of 0.1 µg/ml.
    IHC-Fo: Use at an assay dependent dilution.
    IP: Use at an assay dependent dilution.
    WB: Use at a concentration of 2 µg/ml. Predicted molecular weight: 59 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear recptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.
    • 配列類似性Belongs to the nuclear hormone receptor family. NR2 subfamily.
      Contains 1 nuclear receptor DNA-binding domain.
    • 発生段階Transiently repressed during the meiotic phase of spermatogenesis.
    • 翻訳後修飾Phosphorylation on Ser-19 and Ser-68 is an important regulator of NR2C2-mediated transcriptional activity. Phosphorylation on these residues recruits the corepressor, NRIP1, leading to transcripional repression, whereas the nonphosphorylated form preferentially recruits the coactivator, PCAF.
    • 細胞内局在Nucleus.
    • Information by UniProt
    • 参照データベース
    • 製品の状態There are 2 isoforms produced by alternative splicing.
    • 別名
      • hTAK1 antibody
      • Nr2c2 antibody
      • NR2C2_HUMAN antibody
      • Nuclear hormone receptor TR4 antibody
      • Nuclear receptor subfamily 2 group C member 2 antibody
      • Orphan nuclear receptor TAK1 antibody
      • Orphan nuclear receptor TR4 antibody
      • TAK1 antibody
      • Testicular nuclear receptor 4 antibody
      • Testicular receptor 4 antibody
      • TR2R1 antibody
      • TR4 antibody
      • TR4 nuclear hormone receptor antibody
      see all

    Anti-NR2C2 antibody [H0107B] (ab41954) 使用論文

    ab41954 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab41954.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"