製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to NR0B2
  • アプリケーション
    適用あり: WB, IHC-P, ICC/IFmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment, corresponding to a region within the internal sequence amino acids 64-246 of Human NR0B2.

  • ポジティブ・コントロール
    • Molt-4 cells, SW480 Xenograft

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab96605 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 28 kDa.
IHC-P 1/100 - 1/250.
ICC/IF Use at an assay dependent concentration.

ターゲット情報

  • 機能
    Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1.
  • 組織特異性
    Liver. Low levels of expression were detected in heart and pancreas.
  • 関連疾患
    Obesity
  • 配列類似性
    Belongs to the nuclear hormone receptor family. NR0 subfamily.
  • 翻訳後修飾
    Arginine methylation by PRMT5 enhances repression activity of metabolic genes in liver in response to bile acid signaling, by increasing interaction with cofactors.
  • 細胞内局在
    Nucleus. Cytoplasm. Colocalizes with NEUROD1 in the nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • NR0B2 antibody
    • NR0B2_HUMAN antibody
    • Nr0b2a antibody
    • Nuclear receptor subfamily 0 group B member 2 antibody
    • Nuclear receptor subfamily 0, group B, member 2a antibody
    • Orphan nuclear receptor SHP antibody
    • SHP antibody
    • SHP-1 antibody
    • Shp1 antibody
    • Small heterodimer partner antibody
    see all

画像

  • Anti-NR0B2 antibody (ab96605) at 1/1000 dilution + Molt-4 whole cell lysate at 30 µg

    Predicted band size : 28 kDa
  • Immunohistochemical analysis of paraffin-embedded SW480 Xenograft, using ab96605 at 1:100 dilution.

参考文献

This product has been referenced in:
  • Prestin K  et al. Modulation of expression of the nuclear receptor NR0B2 (small heterodimer partner 1) and its impact on proliferation of renal carcinoma cells. Onco Targets Ther 9:4867-78 (2016). WB ; Human . Read more (PubMed: 27540300) »

See 1 Publication for this product

レビューと Q&A

There are currently no Customer reviews or Questions for ab96605.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

登録