Anti-NR0B2 抗体 (ab80417)

製品の概要

• 製品名Anti-NR0B2 antibody
  NR0B2 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to NR0B2
• アプリケーション適用あり: WB, ELISAmore details
• 種交差性
  交差種: Human
  交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Cow, Dog, Pig, Chimpanzee
• 免疫原

  Synthetic peptide: AAVQWLQCCL ESFWSLELSP KEYACLKGTI LFNPDVPGLQ AASHIGHLQQ , corresponding to internal sequence amino acids 144-193 of Human NR0B2

  Run BLAST with Run BLAST with
• ポジティブ･コントロール
  • Transfected 293T cell lysate.

製品の特性

• 製品の状態Liquid
• 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• バッファーPreservative: None
  Constituents: 2% Sucrose, PBS
• Concentration information loading...
• 精製度Immunogen affinity purified
• ポリ/モノポリクローナル
• アイソタイプIgG
• 研究分野
  • Signal Transduction
  • Signaling Pathway
  • Nuclear Signaling
  • Nuclear Hormone Receptors
  • Retinoic & Retinoid

  • Epigenetics and Nuclear Signaling
  • Nuclear Signaling Pathways
  • Nuclear Receptors
  • Retinoic & Retinoid

  • Signal Transduction
  • Metabolism
  • Lipid metabolism

  • Metabolism
  • Types of disease
  • Cancer

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

アプリケーション

ターゲット情報

• 機能Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1.
• 組織特異性Liver. Low levels of expression were detected in heart and pancreas.
• 関連疾患Obesity
• 配列類似性Belongs to the nuclear hormone receptor family. NR0 subfamily.
• 翻訳後修飾Arginine methylation by PRMT5 enhances repression activity of metabolic genes in liver in response to bile acid signaling, by increasing interaction with cofactors.
• 細胞内局在Nucleus. Cytoplasm. Colocalizes with NEUROD1 in the nucleus.

• Target information above from: UniProt accession Q15466 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 737687 Chimpanzee
  • Entrez Gene: 514770 Cow
  • Entrez Gene: 100070986 Horse
  • Entrez Gene: 8431 Human
  • Entrez Gene: 23957 Mouse
  • Entrez Gene: 100127458 Pig
  • Entrez Gene: 117274 Rat
  • Omim: 604630 Human

  • SwissProt: Q15466 Human
  • SwissProt: Q62227 Mouse
  • SwissProt: P97947 Rat
  • Unigene: 427055 Human
  • Unigene: 346759 Mouse
  • Unigene: 10712 Rat

  see all
• 別名
  • NR0B2 antibody
  • NR0B2_HUMAN antibody
  • Nr0b2a antibody

  • Nuclear receptor subfamily 0 group B member 2 antibody
  • Nuclear receptor subfamily 0, group B, member 2a antibody
  • Orphan nuclear receptor SHP antibody
  • SHP antibody
  • SHP-1 antibody
  • Shp1 antibody
  • Small heterodimer partner antibody

  see all