製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to NOXO1
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide, corresponding to a region within amino acids 307-370 of Human NOXO1 (NP_653204)

  • ポジティブ・コントロール
    • HCT116 whole cell lysate.

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab97788 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000. Predicted molecular weight: 41 kDa.

ターゲット情報

  • 機能
    Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.
  • 組織特異性
    Expressed in testis, small and large intestines, liver, kidney and pancreas. Isoform 3 is mainly expressed in colon. Isoform 1 is preferentially expressed in testis.
  • 配列類似性
    Contains 1 PX (phox homology) domain.
    Contains 2 SH3 domains.
  • 発生段階
    Isoform 3 is expressed in fetal liver.
  • ドメイン
    The PX domain mediates lipid-binding, localization to the plasma membrane and is required for NOX1 activation.
    The SH3 domains mediate interaction with CYBA/p22phox. Also mediates intramolecular interaction with the proline-rich region.
  • 細胞内局在
    Cell membrane. Isoform 3 associates with the plasma membrane in a lipid-dependent manner.
  • Information by UniProt
  • 参照データベース
  • 別名
    • NADPH oxidase organizer 1 antibody
    • NADPH oxidase regulatory protein antibody
    • Nox organizer 1 antibody
    • Nox organizing protein 1 antibody
    • Nox-organizing protein 1 antibody
    • NOXO1 antibody
    • NOXO1_HUMAN antibody
    • P41NOX antibody
    • Regulatory protein P41NOX antibody
    • SH3 and PX domain-containing protein 5 antibody
    • SH3PXD5 antibody
    see all

画像

  • Anti-NOXO1 antibody (ab97788) at 1/1000 dilution + HCT116 whole cell lysate at 30 µg

    Predicted band size : 41 kDa

プロトコール

参考文献

ab97788 has not yet been referenced specifically in any publications.

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