製品の概要

  • 製品名Anti-NOXO1 antibody
    NOXO1 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to NOXO1
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide:

    RGCVDSVPHPTTEQ

    , corresponding to C terminal amino acids 363-376 of Human NOXO1

  • ポジティブ・コントロール
    • Human kidney tissue
  • 特記事項


    This antibody is expected to recognise all three reported isoforms.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab77092 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 10 - 20 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

ターゲット情報

  • 機能Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.
  • 組織特異性Expressed in testis, small and large intestines, liver, kidney and pancreas. Isoform 3 is mainly expressed in colon. Isoform 1 is preferentially expressed in testis.
  • 配列類似性Contains 1 PX (phox homology) domain.
    Contains 2 SH3 domains.
  • 発生段階Isoform 3 is expressed in fetal liver.
  • ドメインThe PX domain mediates lipid-binding, localization to the plasma membrane and is required for NOX1 activation.
    The SH3 domains mediate interaction with CYBA/p22phox. Also mediates intramolecular interaction with the proline-rich region.
  • 細胞内局在Cell membrane. Isoform 3 associates with the plasma membrane in a lipid-dependent manner.
  • Information by UniProt
  • 参照データベース
  • 別名
    • NADPH oxidase organizer 1 antibody
    • NADPH oxidase regulatory protein antibody
    • Nox organizer 1 antibody
    • Nox organizing protein 1 antibody
    • Nox-organizing protein 1 antibody
    • NOXO1 antibody
    • NOXO1_HUMAN antibody
    • P41NOX antibody
    • Regulatory protein P41NOX antibody
    • SH3 and PX domain-containing protein 5 antibody
    • SH3PXD5 antibody
    see all

Anti-NOXO1 antibody 画像

  • Immunohistochemical analysis of paraffin embedded human kidney labelled with ab77092 at 10 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Anti-NOXO1 antibody (ab77092) 使用論文

ab77092 has not yet been referenced specifically in any publications.

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