機能Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.
組織特異性Widely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and colon.
配列類似性Belongs to the NCF2/NOXA1 family. Contains 1 OPR domain. Contains 1 SH3 domain. Contains 4 TPR repeats.
発生段階Expressed in fetal kidney.
ドメインThe SH3 domain mediates interaction with NOXO1 and NCF1 and has autoregulatory function. The TPR repeats mediate interaction with RAC1.
翻訳後修飾Interaction with YWHAZ depends on phosphorylation by PKA.
細胞内局在Cytoplasm. Cell membrane. Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.