Anti-NOTCH4 抗体 [HMN4-14] (Phycoerythrin) (ab95776)

製品の概要

  • 製品名Anti-NOTCH4 antibody [HMN4-14] (Phycoerythrin)
    NOTCH4 一次抗体 製品一覧
  • 製品の詳細
    Armenian Hamster monoclonal [HMN4-14] to NOTCH4 (Phycoerythrin)
  • 標識Phycoerythrin. Ex: 488nm, Em: 575nm
  • アプリケーション適用あり: Flow Cytmore details
  • 種交差性
    交差種: Mouse
  • 免疫原

    Mouse NOTCH4-Fc recombinant protein

  • ポジティブ・コントロール
    • CD8+CD11c+ C57BL/6 splenocytes

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab95776 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt Use 1µg for 105-8 cells.

ターゲット情報

  • 機能Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system.
  • 組織特異性Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes.
  • 配列類似性Belongs to the NOTCH family.
    Contains 5 ANK repeats.
    Contains 28 EGF-like domains.
    Contains 3 LNR (Lin/Notch) repeats.
  • 翻訳後修飾Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane.
    Phosphorylated.
  • 細胞内局在Cell membrane and Nucleus. Following proteolytical processing NICD is translocated to the nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • FLJ16302 antibody
    • hNotch 4 antibody
    • hNotch4 antibody
    • INT3 antibody
    • Neurogenic locus notch homolog protein 4 antibody
    • NOTC4_HUMAN antibody
    • Notch 4 antibody
    • Notch 4 intracellular domain antibody
    • Notch homolog 4 antibody
    • NOTCH3 antibody
    • Notch4 antibody
    • NOTCH4 protein antibody
    see all

Anti-NOTCH4 antibody [HMN4-14] (Phycoerythrin) 画像

  • Flow cytometric analysis of CD8+CD11c+ C57BL/6 splenocytes with 0.25 µg of Armenian Hamster IgG Isotype Control PE (blue histogram) or ab95776 at 0.5 µg (purple histogram). Total viable cells were used for analysis.

Anti-NOTCH4 antibody [HMN4-14] (Phycoerythrin) (ab95776) 使用論文

ab95776 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab95776.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"