製品の概要

  • 製品名Anti-NOTCH3 antibody
    NOTCH3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to NOTCH3
  • アプリケーション適用あり: IHC-Frmore details
  • 種交差性
    交差種: Rat, Human
  • 免疫原

    Synthetic peptide representing the C terminal region of Human NOTCH3.

  • ポジティブ・コントロール
    • Rat cerebellum

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab92758 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-Fr
  • 追加情報IHC-Fr: 1/100 - 1/300.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.
    • 組織特異性Ubiquitously expressed in fetal and adult tissues.
    • 関連疾患Defects in NOTCH3 are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) [MIM:125310]. CADASIL causes a type of stroke and dementia of which key features include recurrent subcortical ischemic events and vascular dementia. The disorder affects relatively young adults of both sexes. Mutations affect highly conserved cysteine residues within epidermal growth factor (EGF)-like repeat domains in the extracellular part of the receptor.
    • 配列類似性Belongs to the NOTCH family.
      Contains 5 ANK repeats.
      Contains 34 EGF-like domains.
      Contains 3 LNR (Lin/Notch) repeats.
    • 翻訳後修飾Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane.
      Phosphorylated.
    • 細胞内局在Cell membrane and Nucleus. Following proteolytical processing NICD is translocated to the nucleus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • CADASIL antibody
      • CASIL antibody
      • NOTC3_HUMAN antibody
      • Notch 3 antibody
      • Notch 3 intracellular domain antibody
      • Notch homolog 3 antibody
      • Notch3 antibody
      see all

    Anti-NOTCH3 antibody 画像

    • ab92758 at 1/100 dilution staining NOTCH3 in (Bergmann glia-10 micron cryostat sections) rat cerebellum by Immunohistochemistry.

    Anti-NOTCH3 antibody (ab92758) 使用論文

    ab92758 has not yet been referenced specifically in any publications.

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