Anti-Notch2 抗体 (ab118824)

製品の概要

• 製品名Anti-Notch2 antibody
  Notch2 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to Notch2
• アプリケーション適用あり: WB, ELISA, IHC-P, ICC/IFmore details
• 種交差性
  交差種: Human
  交差が予測される動物種: Mouse, Rat
• 免疫原

  Synthetic peptide corresponding to Human Notch2 aa 2396-2409 conjugated to Keyhole Limpet Haemocyanin (KLH) (Cysteine residue). Synthetic peptide:

  NAAERTPSHSGHLQ

  conjugated to KLH with a Cysteine residue linker, corresponding to amino acids 2396-2409 of Human Notch2 (NP_077719.2).
  Sequence:

  NAAERTPSHSGHLQ

  
  (Peptide available as ab1387)
  Run BLAST with Run BLAST with
• ポジティブ･コントロール
  • Human kidney tissue.

製品の特性

• 製品の状態Liquid
• 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• バッファーpH: 7.20
  Preservative: 0.1% Sodium azide
  Constituents: 0.27% Potassium phosphate, 0.88% Sodium chloride, 98% Whole serum
• 精製度Whole antiserum
• ポリ/モノポリクローナル
• アイソタイプIgG
• 研究分野
  • Neuroscience
  • Neurology process
  • Notch Pathway

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Other factors

  • Stem Cells
  • Signaling Pathways
  • Notch
  • Surface Molecules

  • Stem Cells
  • Signaling Pathways
  • Notch
  • Nuclear

  • Stem Cells
  • Neural Stem Cells
  • Surface Molecules

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

アプリケーション

ターゲット情報

• 機能Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells (PubMed:25985737).
• 組織特異性Expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Ubiquitously expressed in the embryo.
• 関連疾患Alagille syndrome 2
  Hajdu-Cheney syndrome
• 配列類似性Belongs to the NOTCH family.
  Contains 6 ANK repeats.
  Contains 35 EGF-like domains.
  Contains 3 LNR (Lin/Notch) repeats.
• 翻訳後修飾Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane.
  Hydroxylated by HIF1AN.
  Can be either O-glucosylated or O-xylosylated at Ser-613 by POGLUT1.
• 細胞内局在Cell membrane and Nucleus. Cytoplasm. Following proteolytical processing NICD is translocated to the nucleus. Retained at the cytoplasm by C8orf4 (PubMed:25985737).

• Target information above from: UniProt accession Q04721 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 4853 Human
  • Entrez Gene: 18129 Mouse
  • Omim: 600275 Human
  • SwissProt: Q04721 Human
  • SwissProt: O35516 Mouse
  • SwissProt: Q9QW30 Rat
  • Unigene: 487360 Human
  • Unigene: 485843 Mouse
• 別名
  • AGS2 antibody
  • hN2 antibody
  • Motch B antibody

  • N2 antibody
  • N2ECD antibody
  • N2ICD antibody
  • neurogenic locus notch homolog protein 2 antibody
  • NOTC2_HUMAN antibody
  • Notch 2 antibody
  • Notch 2 intracellular domain antibody
  • Notch Drosophila homolog 2 antibody
  • Notch homolog 2 antibody
  • Notch homolog 2 Drosophila antibody
  • Notch2 antibody

  see all