Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.
Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen. Present in vascular endothelial cells and placenta. Over-expressed in placenta from women with pre-eclampsia (at protein level).
Contains 1 FCH domain. Contains 1 SH3 domain.
The SH3 domain mediates interaction with NOS3, DNM2 and WASL. The FCH domain is necessary for membrane targeting.