製品の概要

  • 製品名Anti-NORE1 antibody
    NORE1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to NORE1
  • 特異性Ab33292 recognises NORE1 protein.
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide:

    DNPQKFALFKRIHKDGQ

    , corresponding to amino acids 313-329 of NORE1. This sequence is located in the RA domain of NORE1.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab33292 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 44 kDa.

ターゲット情報

  • 機能Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4 complex may mediate HRAS1 and KRAS induced apoptosis.
  • 組織特異性Widely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors.
  • 配列類似性Contains 1 phorbol-ester/DAG-type zinc finger.
    Contains 1 Ras-associating domain.
    Contains 1 SARAH domain.
  • 細胞内局在Cytoplasm. Cytoplasm > cytoskeleton. Isoform 2 is mainly located in the perinuclear region of unstimulated primary T cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Maxp 1 antibody
    • MAXP1 antibody
    • MGC10823 antibody
    • MGC17344 antibody
    • New ras effector 1 antibody
    • NORE 1 antibody
    • NORE1A antibody
    • NORE1B antibody
    • Novel Ras effector 1 antibody
    • RAP1 Binding Protein antibody
    • RAPL antibody
    • Ras association (RalGDS/AF 6) domain family 5 antibody
    • Ras association (RalGDS/AF 6) domain family member 5 antibody
    • Ras association domain containing family protein 5 antibody
    • Ras association domain-containing protein 5 antibody
    • Ras effector like protein antibody
    • RASF5_HUMAN antibody
    • RASSF 3 antibody
    • RASSF 5 antibody
    • RASSF3 antibody
    • RASSF5 antibody
    • Regulator for cell adhesion and polarization enriched in lymphoid tissue antibody
    • Regulator for cell adhesion and polarization enriched in lymphoid tissues antibody
    • Tumor suppressor RASSF3 antibody
    see all

Anti-NORE1 antibody (ab33292) 使用論文

ab33292 has not yet been referenced specifically in any publications.

Product Wall

Vielen Dank für Ihren Anruf und für Ihr Interesse an unseren Produkten. Wie gerade besprochen, wissen wir nicht mit Sicherheit, welche Isoformen der NORE1-Antikörper ab33292 erkennt, und auch haben wir noch keine Abbildung. Falls Sie uns eine Abbild...

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Thank you for your enquiry. With reference to the three NORE1 antibodies that we sell I have further information relating to the likely cross reactivity shown by two of the antibodies; ab16757: The sequence used to raise this antibody is shared b...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"