製品の概要

  • 製品名Anti-NOP10 antibody
    NOP10 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to NOP10
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Pig, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within internal amino acids 1-50 (MFLQYYLNEQ GDRVYTLKKF DPMGQQTCSA HPARFSPDDK YSRHRITIKK) of Human NOLA3 (NP_061118).

  • ポジティブ・コントロール
    • Jurkat cell lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab99084 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 8 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
  • 関連疾患Defects in NOP10 are a cause of dyskeratosis congenita autosomal recessive (ARDKC) [MIM:224230]. ARDKC is a rare, progressive bone marrow failure syndrome characterized by the triad of reticulated skin hyperpigmentation, nail dystrophy, and mucosal leukoplakia. Early mortality is often associated with bone marrow failure, infections, fatal pulmonary complications, or malignancy.
  • 配列類似性Belongs to the NOP10 family.
  • 細胞内局在Nucleus > nucleolus. Nucleus > Cajal body. Also localized to Cajal bodies.
  • Information by UniProt
  • 参照データベース
  • 別名
    • DKCB1 antibody
    • H/ACA ribonucleoprotein complex subunit 3 antibody
    • homolog of yeast Nop10p antibody
    • MGC70651 antibody
    • NOLA3 antibody
    • NOP10 antibody
    • NOP10 ribonucleoprotein homolog (yeast) antibody
    • NOP10_HUMAN antibody
    • NOP10P antibody
    • Nucleolar protein 10 antibody
    • Nucleolar protein family A member 3 antibody
    • nucleolar protein family A, member 3 (H/ACA small nucleolar RNPs) antibody
    • snoRNP protein NOP10 antibody
    see all

Anti-NOP10 antibody 画像

  • Anti-NOP10 antibody (ab99084) at 1 µg/ml + Jurkat cell lysate at 10 µg

    Predicted band size : 8 kDa

Anti-NOP10 antibody (ab99084) 使用論文

ab99084 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"