製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to Nociceptin
  • アプリケーション
    適用あり: IHC-P, ICCmore details
  • 種交差性
    交差種: Mouse, Rat, Human
    交差が予測される動物種: Rabbit, Horse, Dog, Pig
  • 免疫原

    Synthetic peptide:

    FGGFTGARKSARKLANQ

    , corresponding to internal sequence amino acids 130-146 of Human Nociceptin

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab100880 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/2000.
ICC 1/5000.

ターゲット情報

  • 機能
    Nociceptin: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development.
    Nocistatin: Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia.
    Orphanin FQ2: Has potent analgesic activity.
  • 組織特異性
    Predominantly expressed in the brain and spinal cord. Also expressed and secreted by peripheral blood neutrophils following degranulation.
  • 配列類似性
    Belongs to the opioid neuropeptide precursor family.
  • 翻訳後修飾
    Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin.
    The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
  • 細胞内局在
    Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • N/OFQ antibody
    • N23K antibody
    • N23K/N27K antibody
    • Nociceptin, included antibody
    • nocistatin antibody
    • Npnc1 antibody
    • OFQ antibody
    • OFQ/N antibody
    • Orphanin FQ antibody
    • Orphanin FQ2 antibody
    • Pnoc antibody
    • PNOC_HUMAN antibody
    • ppN/OFQ antibody
    • PPNOC antibody
    • pre-pro-N/OFQ antibody
    • prepronociceptin antibody
    • pronociceptin antibody
    • Propronociceptin antibody
    see all

画像

  • Dual labeling of Nociceptin (green) and enkephalin (red).

参考文献

ab100880 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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