製品の概要

  • 製品名
    NNC 05-2090
  • 製品の詳細
    GABA uptake inhibitor
  • 生理活性の詳細
    GABA uptake inhibitor, selective for the BGT-1 transporter (Ki values are 1.4 (BGT-1), 19 (GAT-1), 41 (GAT-2) and 15 μM (GAT-3)). Also active at α1- and D2-receptors (IC50 values are 266 and 1632 nM, respectively). Anticonvulsant in vivo.
  • 精製度
    > 99%

製品の特性

参考文献

This product has been referenced in:
  • Thomsen C  et al. 1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter. Br J Pharmacol 120:983-5 (1997). Read more (PubMed: 9134205) »
  • Dalby NO  et al. Anticonvulsant properties of two GABA uptake inhibitors NNC 05-2045 and NNC 05-2090, not acting preferentially on GAT-1. Epilepsy Res 28:51-61 (1997). Read more (PubMed: 9255599) »

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