製品の概要

  • 製品名Anti-NMRAL1 antibody
    NMRAL1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to NMRAL1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse
    交差が予測される動物種: Rat, Pig
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 11-60 (GATGAQGGSV ARALLEDGTF RIRVVTRNPE QRAAKELKQQ GAEVVRGDQD) of Mouse NMRAL1 (NP_080669)

  • ポジティブ・コントロール
    • Mouse heart lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab105801 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 33 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer.
  • 配列類似性Belongs to the NmrA-type oxidoreductase family.
  • 細胞内局在Cytoplasm. Cytoplasm > perinuclear region. Nucleus. Under normal redox growth conditions localizes in the cytoplasm and perinuclear region. Nuclear localization is promoted by increased intracellular nitric oxide and reduced NADPH/NADP(+) ratios.
  • Information by UniProt
  • 参照データベース
  • 別名
    • FLJ25918 antibody
    • HSCARG antibody
    • NmrA like family domain containing 1 antibody
    • NmrA like family domain containing protein 1 antibody
    • NmrA-like family domain-containing protein 1 antibody
    • NMRAL1 antibody
    • NMRL1_HUMAN antibody
    • SDR48A1 antibody
    see all

Anti-NMRAL1 antibody 画像

  • Anti-NMRAL1 antibody (ab105801) at 1 µg/ml + Mouse heart lysate at 10 µg

    Predicted band size : 33 kDa

Anti-NMRAL1 antibody (ab105801) 使用論文

ab105801 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"