製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to NMNAT3
  • 特異性
    ab123807 is expected to recognize both reported isoforms (NP_835471.1; NP_001186976.1).
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Horse, Dog
  • 免疫原

    Synthetic peptide:

    C-QHNIHLAKEPVQNE

    , corresponding to internal sequence amino acids 149-162 of Human NMNAT3 isoform 2 and 186-199 of Human NMNAT3 isoform 1 (NP_001186976.1. NP_835471.1).

  • ポジティブ・コントロール
    • Human kidney lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab123807 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 26 kDa (predicted molecular weight: 24 kDa).

ターゲット情報

  • 機能
    Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD (+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following injury.
  • 組織特異性
    Expressed in lung and spleen with lower levels in placenta and kidney.
  • パスウェイ
    Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.
  • 配列類似性
    Belongs to the eukaryotic NMN adenylyltransferase family.
  • 細胞内局在
    Mitochondrion.
  • Information by UniProt
  • 参照データベース
  • 別名
    • NaMN adenylyltransferase 3 antibody
    • Nicotinamide mononucleotide adenylyltransferase 3 antibody
    • Nicotinamide nucleotide adenylyltransferase 3 antibody
    • Nicotinate-nucleotide adenylyltransferase 3 antibody
    • NMN adenylyltransferase 3 antibody
    • NMNA3_HUMAN antibody
    • NMNAT 3 antibody
    • Nmnat3 antibody
    • PNAT 3 antibody
    • PNAT-3 antibody
    • PNAT3 antibody
    • Pyridine nucleotide adenylyltransferase 3 antibody
    see all

画像

  • Anti-NMNAT3 antibody (ab123807) at 0.1 µg/ml + Human Kidney lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 24 kDa

プロトコール

参考文献

ab123807 has not yet been referenced specifically in any publications.

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