Anti-NLRX1 抗体 (ab105412)

製品の概要

• 製品名
  Anti-NLRX1 antibody
  NLRX1 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to NLRX1
• 特異性
  At least two isoforms of NLRX1 are known to exist; ab105412 will recognize both. This antibody is predicted to not crossreact with other NLRP family members.
• アプリケーション
  適用あり: ICC/IF, WB, ICCmore details
• 種交差性
  交差種: Mouse, Rat, Human
  
• 免疫原

  A 14 amino acid peptide near the amino terminus of Human NLRX1 (NP_078894).

• ポジティブ･コントロール
  • Rat spleen tissue lysate

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Store at +4°C.
• バッファー
  Preservative: 0.02% Sodium Azide
  Constituents: PBS
• Concentration information loading...
• 精製度
  Immunogen affinity purified
• ポリ/モノ
  ポリクローナル
• アイソタイプ
  IgG
• 研究分野
  • Immunology
  • Innate Immunity
  • Macrophage / Inflamm.

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

アプリケーション

ターゲット情報

• 機能
  Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).
• 組織特異性
  Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HELA, 293T, THP-1, HL60, RAJI, and JURKAT cell lines (at protein level).
• 配列類似性
  Belongs to the NLRP family.
  Contains 7 LRR (leucine-rich) repeats.
  Contains 1 NACHT domain.
• 細胞内局在
  Mitochondrion outer membrane.

• Target information above from: UniProt accession Q86UT6 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 79671 Human
  • Entrez Gene: 270151 Mouse
  • Entrez Gene: 315599 Rat
  • Omim: 611947 Human
  • SwissProt: Q86UT6 Human
  • SwissProt: Q3TL44 Mouse
  • SwissProt: Q5FVQ8 Rat
  • Unigene: 524082 Human

  • Unigene: 3957 Mouse
  • Unigene: 12444 Rat

  see all
• 別名
  • Caterpiller protein 11.3 antibody
  • CLR11.3 antibody
  • DLNB26 antibody

  • FLJ21478 antibody
  • MGC131937 antibody
  • MGC21025 antibody
  • NLR family member X1 antibody
  • NLR family, X1 antibody
  • Nlrx1 antibody
  • NLRX1_HUMAN antibody
  • NOD-like receptor X1 antibody
  • NOD26 antibody
  • NOD5 antibody
  • NOD9 antibody
  • Nucleotide-binding oligomerization domain protein 26 antibody
  • Nucleotide-binding oligomerization domain protein 5 antibody
  • Nucleotide-binding oligomerization domain protein 9 antibody
  • nucleotide-binding oligomerization domain, leucine rich repeat containing X1 antibody
  • Protein Caterpiller 11.3 antibody

  see all

プロトコール

• Western blot protocols
• Immunocytochemistry & immunofluorescence protocols