製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to nkx6.1
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Cow, Dog, Pig, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 2 - 51 (LAVGAMEGTR QSAFLLSSPP LAALHSMAEM KTPLYPAAYP PLPAGPPSSS) of Human nkx6.1 (NP_006159).

  • ポジティブ・コントロール
    • Human fetal small intestine lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab90706 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 38 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能
    Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in regulation of the insulin gene. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals.
  • 組織特異性
    Pancreatic beta cells.
  • 配列類似性
    Contains 1 homeobox DNA-binding domain.
  • ドメイン
    The C-terminal domain contributes to sequence-specific DNA-binding.
  • 細胞内局在
    Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Homeobox protein NK-6 homolog A antibody
    • Homeobox protein Nkx-6.1 antibody
    • NK homeo box, family 6, member A antibody
    • NK homeobox (Drosophila), family 6, A antibody
    • NK homeobox, family 6, A antibody
    • NK6 homeobox 1 antibody
    • NK6 transcription factor homolog A antibody
    • NK6 transcription factor related, locus 1 antibody
    • NK6 transcription factor related, locus 1 (Drosophila) antibody
    • NKX6-1 antibody
    • NKX6.1 antibody
    • NKX61 antibody
    • NKX61_HUMAN antibody
    • NKX6A antibody
    see all

画像

  • Anti-nkx6.1 antibody (ab90706) at 1 µg/ml (in 5% skim milk / PBS buffer) + Human fetal small intestine lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 38 kDa

プロトコール

参考文献

This product has been referenced in:
  • Wheeler E  et al. Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity. Nat Genet 45:513-7 (2013). Human . Read more (PubMed: 23563609) »

See 1 Publication for this product

レビューと Q&A

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