This fast track antibody is not yet fully characterized. It is subject to these terms and conditions

Anti-Niemann Pick C1 Like 1 抗体 (ab121037)

製品の概要

製品の特性

アプリケーション

Fast track antibodies constitute a diverse group of products that have been released to accelerate your research, but are not yet fully characterized. They have all been affinity purified and show high titre values against the immunizing peptide (by ELISA). Fast track terms of use

アプリケーション Abreviews 特記事項
WB Use at an assay dependent concentration. Preliminary experiments in Mouse and Rat Liver and Lung lysates gave no specific signal but low background (at antibody concentration up to 1µg/ml).

ターゲット情報

  • 機能Play a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorbtion. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism.
  • 組織特異性Widely expressed. Expressed in liver. Also expressed in small intestine, pancreas, kidney, lung, pancreas, spleen, heart, gall bladder, brain, testis, stomach and muscle.
  • 配列類似性Belongs to the patched family.
    Contains 1 SSD (sterol-sensing) domain.
  • 翻訳後修飾Highly glycosylated.
  • 細胞内局在Apical cell membrane. Cell membrane. Cytoplasmic vesicle membrane. Subfractionation of brush border membranes from proximal enterocytes suggests considerable association with the apical membrane fraction. Exists as a predominantly cell surface membrane expressed protein (By similarity). According to PubMed:15671032, localizes in a subcellular vesicular compartment rich in RAB5.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Niemann Pick C1 like protein 1 antibody
    • Niemann Pick disease type C1 gene like 1 antibody
    • Niemann-Pick C1-like protein 1 antibody
    • NPC1 LIKE 1 antibody
    • NPC1 Niemann Pick disease type C1 gene like 1 antibody
    • NPC1L1 antibody
    • NPC1L1 splice variant antibody
    • NPCL1_HUMAN antibody
    • Truncated Niemann Pick C1 like protein 1 antibody
    see all

Anti-Niemann Pick C1 Like 1 antibody (ab121037) 使用論文

ab121037 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"