Anti-Nicotinic Acetylcholine Receptor gamma 抗体 [C9] (ab11151)

製品の概要

  • 製品名Anti-Nicotinic Acetylcholine Receptor gamma antibody [C9]
    Nicotinic Acetylcholine Receptor gamma 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [C9] to Nicotinic Acetylcholine Receptor gamma
  • 特異性ab11151 binds to Human AChR - gamma subunit found only in foetal AChR. Exhibits homogenous, high avidity binding to the receptor. Binds human recombinant gamma subunit on Western blots.
  • アプリケーション適用あり: IHC-Fr, IP, WB, Flow Cytmore details
  • 種交差性
    交差種: Human
    非交差種: Mouse, Rat, Chicken
  • 免疫原

    Full length protein (Human).

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 精製度Ascites
  • ポリ/モノモノクローナル
  • クローン名C9
  • ミエローマNS1
  • アイソタイプIgG1
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab11151 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-Fr 1/3.
IP 1/100.
WB 1/100. Predicted molecular weight: 62.4 kDa.
Flow Cyt 1/1. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

ターゲット情報

  • 機能After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • 関連疾患Defects in CHRNG are a cause of multiple pterygium syndrome lethal type (MUPSL) [MIM:253290]. Multiple pterygia are found infrequently in children with arthrogryposis and in fetuses with fetal akinesia syndrome. In lethal multiple pterygium syndrome there is intrauterine growth retardation, multiple pterygia, and flexion contractures causing severe arthrogryposis and fetal akinesia. Subcutaneous edema can be severe, causing fetal hydrops with cystic hygroma and lung hypoplasia. Oligohydramnios and facial anomalies are frequent.
    Defects in CHRNG are a cause of multiple pterygium syndrome Escobar variant (MUPSE) [MIM:265000]; also known as nonlethal type multiple pterygium syndrome. Escobar syndrome is a non-lethal form of arthrogryposis multiplex congenita. It is an autosomal recessive condition characterized by excessive webbing (pterygia), congenital contractures (arthrogryposis), and scoliosis. Variable other features include intrauterine death, congenital respiratory distress, short stature, faciocranial dysmorphism, ptosis, low-set ears, arachnodactyly and cryptorchism in males. Congenital contractures are common and may be caused by reduced fetal movements at sensitive times of development. Possible causes of decreased fetal mobility include space constraints such as oligohydramnion, drugs, metabolic conditions or neuromuscular disorders including myasthenia gravis. is a.
  • 配列類似性Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Gamma/CHRNG sub-subfamily.
  • 細胞内局在Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Acetylcholine receptor muscle gamma subunit antibody
    • Acetylcholine receptor protein gamma chain precursor antibody
    • Acetylcholine receptor subunit gamma antibody
    • ACHG antibody
    • ACHG_HUMAN antibody
    • Achr 3 antibody
    • AChR antibody
    • Achr3 antibody
    • ACHRG antibody
    • ACRG antibody
    • Cholinergic receptor nicotinic gamma antibody
    • Cholinergic receptor nicotinic gamma polypeptide antibody
    • CHRNG antibody
    • MGC133376 antibody
    see all

Anti-Nicotinic Acetylcholine Receptor gamma antibody [C9] (ab11151) 使用論文

ab11151 has not yet been referenced specifically in any publications.

Product Wall

Application Western blot
Loading amount 25 µg
Gel Running Conditions Non-reduced Denaturing (10% gel BioRad, Running Buffer BioRad)
Sample Mouse Tissue lysate - whole (tibialis muscle)
Specification tibialis muscle
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 26°C
Username

Ms. Lisa Marienhoff

Verified customer

投稿 Nov 05 2013

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"