Anti-Nicotinic Acetylcholine Receptor epsilon 抗体 (ab65180)

製品の概要

  • 製品名
    Anti-Nicotinic Acetylcholine Receptor epsilon antibody
    Nicotinic Acetylcholine Receptor epsilon 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Nicotinic Acetylcholine Receptor epsilon
  • アプリケーション
    適用あり: IHC-P, WBmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Rat, a wide range of other species
  • 免疫原

    Synthetic peptide derived from C terminal human Nicotinic Acetylcholine Receptor epsilon.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab65180 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use at an assay dependent concentration.
WB 1/500 - 1/5000. Predicted molecular weight: 55 kDa.

ターゲット情報

  • 機能
    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • 関連疾患
    The muscle AChR is the major target antigen in the autoimmune disease myasthenia gravis. Myasthenia gravis is characterized by sporadic muscular fatigability and weakness, occurring chiefly in muscles innervated by cranial nerves, and characteristically improved by cholinesterase-inhibiting drugs.
    Myasthenic syndrome, congenital, 4A, slow-channel
    Myasthenic syndrome, congenital, 4B, fast-channel
    Myasthenic syndrome, congenital, 4C, associated with acetylcholine receptor deficiency
  • 配列類似性
    Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Epsilon/CHRNE sub-subfamily.
  • 細胞内局在
    Cell junction, synapse, postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Acetylcholine receptor subunit epsilon antibody
    • ACHE_HUMAN antibody
    • AChR antibody
    • AchR epsilon subunit antibody
    • ACHRE antibody
    • Cholinergic receptor, nicotinic, epsilon polypeptide antibody
    • Chrne antibody
    • CMS1D antibody
    • CMS1E antibody
    • CMS2A antibody
    • FCCMS antibody
    • SCCMS antibody
    see all

参考文献

This product has been referenced in:
  • Saeed S  et al. Conformational co-dependence between Plasmodium berghei LCCL proteins promotes complex formation and stability. Mol Biochem Parasitol 185:170-3 (2012). Read more (PubMed: 22877575) »

See 1 Publication for this product

レビューと Q&A

Application
Western blot
Loading amount
25 µg
Gel Running Conditions
Non-reduced Denaturing (10% gel BioRad, Running Buffer BioRad.)
Sample
Mouse Tissue lysate - whole (tibialis muscle)
Specification
tibialis muscle
Blocking step
Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 26°C
Username

Ms. Lisa Marienhoff

Verified customer

投稿 Dec 03 2013

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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