Anti-Nicotinic Acetylcholine Receptor epsilon 抗体 (ab49141)

製品の概要

  • 製品名Anti-Nicotinic Acetylcholine Receptor epsilon antibody
    Nicotinic Acetylcholine Receptor epsilon 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Nicotinic Acetylcholine Receptor epsilon
  • アプリケーション適用あり: ELISA, WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow
  • 免疫原

    A region within synthetic peptide: PGSRPVREPE DTVTISLKVT LTNLISLNEK EETLTTSVWI GIDWQDYRLN, corresponding to N terminal amino acids 37-86 of Human Nicotinic Acetylcholine Receptor epsilon

  • ポジティブ・コントロール
    • HepG2 cell lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab49141 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA Use at an assay dependent concentration.

ELISA titre using peptide based assay: 1/375,000.

WB Use a concentration of 1.25 µg/ml. Detects a band of approximately 55 kDa (predicted molecular weight: 55 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • 関連疾患The muscle AChR is the major target antigen in the autoimmune disease myasthenia gravis. Myasthenia gravis is characterized by sporadic muscular fatigability and weakness, occurring chiefly in muscles innervated by cranial nerves, and characteristically improved by cholinesterase-inhibiting drugs.
    Myasthenic syndrome, congenital, 4A, slow-channel
    Myasthenic syndrome, congenital, 4B, fast-channel
    Myasthenic syndrome, congenital, 4C, associated with acetylcholine receptor deficiency
  • 配列類似性Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Epsilon/CHRNE sub-subfamily.
  • 細胞内局在Cell junction, synapse, postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Acetylcholine receptor subunit epsilon antibody
    • ACHE_HUMAN antibody
    • AChR antibody
    • AchR epsilon subunit antibody
    • ACHRE antibody
    • Cholinergic receptor, nicotinic, epsilon polypeptide antibody
    • Chrne antibody
    • CMS1D antibody
    • CMS1E antibody
    • CMS2A antibody
    • FCCMS antibody
    • SCCMS antibody
    see all

Anti-Nicotinic Acetylcholine Receptor epsilon antibody 画像

  • Anti-Nicotinic Acetylcholine Receptor epsilon antibody (ab49141) at 1.25 µg/ml + HepG2 Cell Lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50,000

    Predicted band size : 55 kDa
    Observed band size : 55 kDa

Anti-Nicotinic Acetylcholine Receptor epsilon antibody (ab49141) 使用論文

This product has been referenced in:
  • Mastrangelo L  et al. Serotonin receptors, novel targets of sulforaphane identified by proteomic analysis in Caco-2 cells. Cancer Res 68:5487-91 (2008). WB ; Human . Read more (PubMed: 18593952) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"