Anti-Nicotinic Acetylcholine Receptor beta 抗体 [B3] (ab11150)

製品の概要

  • 製品名Anti-Nicotinic Acetylcholine Receptor beta antibody [B3]
    Nicotinic Acetylcholine Receptor beta 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [B3] to Nicotinic Acetylcholine Receptor beta
  • 特異性Ab11150 binds human AChR Beta subunit. Exhibits homogenous, high avidity binding to the receptor. Binding to recombinant beta subunit demonstrated on Western blotting.
  • アプリケーション適用あり: Flow Cyt, IHC-Fr, WB, IPmore details
  • 種交差性
    交差種: Human
    非交差種: Mouse, Rat, Chicken
  • 免疫原

    Full length protein (Human).

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 精製度Protein G purified
  • ポリ/モノモノクローナル
  • クローン名B3
  • ミエローマNS1
  • アイソタイプIgG1
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab11150 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt 1/1. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
IHC-Fr 1/3.
WB 1/100. Predicted molecular weight: 60.1 kDa.
IP 1/100.

ターゲット情報

  • 機能After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • 関連疾患Defects in CHRNB1 are a cause of congenital myasthenic syndrome slow-channel type (SCCMS) [MIM:601462]. SCCMS is the most common congenital myasthenic syndrome. Congenital myasthenic syndromes are characterized by muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. SCCMS is caused by kinetic abnormalities of the AChR, resulting in prolonged endplate currents and prolonged AChR channel opening episodes.
    Defects in CHRNB1 are a cause of congenital myasthenic syndrome with acetylcholine receptor deficiency (ACHRDCMS) [MIM:608931]. ACHRDCMS is a post-synaptic congenital myasthenic syndrome. Mutations underlying AChR deficiency cause a 'loss of function' and show recessive inheritance.
  • 配列類似性Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-1/CHRNB1 sub-subfamily.
  • 細胞内局在Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Acetylcholine receptor protein beta chain precursor antibody
    • Acetylcholine receptor subunit beta antibody
    • ACHB_HUMAN antibody
    • AChR antibody
    • ACHRB antibody
    • Cholinergic receptor nicotinic beta polypeptide 1 (muscle) antibody
    • Chrnb 1 antibody
    • CHRNB antibody
    • chrnb1 antibody
    • CMS1D antibody
    • CMS2A antibody
    • Nicotinic acetylcholine receptor beta subunit precursor antibody
    • SCCMS antibody
    see all

Anti-Nicotinic Acetylcholine Receptor beta antibody [B3] (ab11150) 使用論文

ab11150 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"