Anti-Nicotinic Acetylcholine Receptor beta 抗体 (ab81982)


  • 製品名Anti-Nicotinic Acetylcholine Receptor beta antibody
    Nicotinic Acetylcholine Receptor beta 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to Nicotinic Acetylcholine Receptor beta
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow
  • 免疫原

    Synthetic peptide:


    , corresponding to internal sequence amino acids 448-459 of Human Nicotinic Acetylcholine Receptor beta (NP_000738.2).

  • ポジティブ・コントロール
    • Human brain (cerebellum, hippocampus, frontal cortex) lysates.


  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris saline, pH 7.3
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab81982 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野


Our Abpromise guarantee covers the use of ab81982 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
  • 追加情報Peptide ELISA: Antibody detection limit dilution 1/1000.
    WB: Use at a concentration of 1 - 3 µg/ml. Detects a band of approximately 57 kDa (predicted molecular weight: 57 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
    • 関連疾患Defects in CHRNB1 are a cause of congenital myasthenic syndrome slow-channel type (SCCMS) [MIM:601462]. SCCMS is the most common congenital myasthenic syndrome. Congenital myasthenic syndromes are characterized by muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. SCCMS is caused by kinetic abnormalities of the AChR, resulting in prolonged endplate currents and prolonged AChR channel opening episodes.
      Defects in CHRNB1 are a cause of congenital myasthenic syndrome with acetylcholine receptor deficiency (ACHRDCMS) [MIM:608931]. ACHRDCMS is a post-synaptic congenital myasthenic syndrome. Mutations underlying AChR deficiency cause a 'loss of function' and show recessive inheritance.
    • 配列類似性Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-1/CHRNB1 sub-subfamily.
    • 細胞内局在Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Acetylcholine receptor protein beta chain precursor antibody
      • Acetylcholine receptor subunit beta antibody
      • ACHB_HUMAN antibody
      • AChR antibody
      • ACHRB antibody
      • Cholinergic receptor nicotinic beta polypeptide 1 (muscle) antibody
      • Chrnb 1 antibody
      • CHRNB antibody
      • chrnb1 antibody
      • CMS1D antibody
      • CMS2A antibody
      • Nicotinic acetylcholine receptor beta subunit precursor antibody
      • SCCMS antibody
      see all

    Anti-Nicotinic Acetylcholine Receptor beta antibody 画像

    • Anti-Nicotinic Acetylcholine Receptor beta antibody (ab81982) at 1 µg/ml + human cerebellum lysate in RIPA buffer at 35 µg

      Predicted band size : 57 kDa
      Observed band size : 57 kDa

    Anti-Nicotinic Acetylcholine Receptor beta antibody (ab81982) 使用論文

    ab81982 has not yet been referenced specifically in any publications.

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