製品の概要

  • 製品名Nicotinamide
  • 製品の詳細
    Amide form of vitamin B3
  • 生理活性の詳細Amide form of vitamin B3. Plasma membrane and blood-brain barrier permeable. Precursor for β-nicotinamide adenine dinucleotide (NAD+). Essential for the synthesis of NAD+ phosphate (NADP+). Essential for energy metabolism, normal physiology and disease progression. Associated with a number of signaling pathways including oxidative stress, cell survival and inflammation. These effects are orchestrated partly through forkhead, Akt, Bad, caspase, MAPK and PARP signaling. Non-selective sirtuin inhibitor.
  • 精製度> 99%

製品の特性

    Nicotinamide (ab120864) 使用論文

    This product has been referenced in:
    • Wang H  et al. Different effects of histone deacetylase inhibitors nicotinamide and trichostatin A (TSA) in C17.2 neural stem cells. J Neural Transm : (2012). Read more (PubMed: 22407380) »
    • Maiese K  et al. The vitamin nicotinamide: translating nutrition into clinical care. Molecules 14:3446-85 (2009). Read more (PubMed: 19783937) »
    • Kaneko S  et al. Protecting axonal degeneration by increasing nicotinamide adenine dinucleotide levels in experimental autoimmune encephalomyelitis models. J Neurosci 26:9794-804 (2006). Read more (PubMed: 16988050) »
    • Avalos JL  et al. Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme. Mol Cell 17:855-68 (2005). Read more (PubMed: 15780941) »

    See all 2 Publications for this product

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