製品の概要

製品の詳細

  • 由来
    Synthetic

関連製品

特性

Our Abpromise guarantee covers the use of ab4977 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 製品の状態
    Liquid
  • 備考


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human nicastrin, catalog ab3444. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

関連情報

  • 別名
    • Anterior pharynx defective 2
    • APH 2
    • APH2
    • ATAG1874
    • KIAA0253
    • Ncstn
    • NCT
    • NICA_HUMAN
    • Nicastrin
    • RP11 517F10.1
    • RP11517F101
    see all
  • 機能
    Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
  • 組織特異性
    Widely expressed.
  • 配列類似性
    Belongs to the nicastrin family.
  • 細胞内局在
    Membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt

参考文献

ab4977 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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