製品の概要

  • 製品名Anti-Nicastrin antibody [EPR2574]
    Nicastrin 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [EPR2574] to Nicastrin
  • アプリケーション適用あり: WB, ICCmore details
    適用なし: Flow Cyt,IHC-P or IP
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic peptide corresponding to residues in Human Nicastrin.

  • ポジティブ・コントロール
    • A431, Jurkat, HeLa and 293T cell lysates
  • 特記事項

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab108993 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000 - 1/10000. Predicted molecular weight: 78 kDa.
ICC 1/100 - 1/250.
  • 追加情報Is unsuitable for Flow Cyt,IHC-P or IP.
  • ターゲット情報

    • 機能Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
    • 組織特異性Widely expressed.
    • 配列類似性Belongs to the nicastrin family.
    • 細胞内局在Membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Anterior pharynx defective 2 antibody
      • APH 2 antibody
      • APH2 antibody
      • ATAG1874 antibody
      • KIAA0253 antibody
      • Ncstn antibody
      • NCT antibody
      • NICA_HUMAN antibody
      • Nicastrin antibody
      • RP11 517F10.1 antibody
      • RP11517F101 antibody
      see all

    Anti-Nicastrin antibody [EPR2574] 画像

    • All lanes : Anti-Nicastrin antibody [EPR2574] (ab108993) at 1/1000 dilution

      Lane 1 : A431 cell lysate
      Lane 2 : Jurkat cell lysate
      Lane 3 : HeLa cell lysate
      Lane 4 : 293T cell lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 78 kDa

    Anti-Nicastrin antibody [EPR2574] (ab108993) 使用論文

    ab108993 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab108993.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"