NG-Monomethyl-L-arginine, monoacetate salt (L-NMMA), NOS inhibitor (ab120137)
Key features and details
- NOS inhibitor
- CAS Number: 53308-83-1
- Soluble in water to 50 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
NG-Monomethyl-L-arginine, monoacetate salt (L-NMMA), NOS inhibitor -
製品の詳細
NOS inhibitor -
別名
- L-NMMA
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生理活性の詳細
Cell-permeable competitive NOS inhibitor. (Ki values are 700 nM, 3.9 µM and 650 nM for eNOS, iNOS and nNOS, respectively).
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CAS 番号
53308-83-1 -
構造式
製品の特性
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体系名
NG-Methyl-L-arginine acetate -
分子量
248.28 -
分子式
C7H16N4O2.CH3CO2H -
PubChem 登録番号
135242 -
保存方法
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 50 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
N[C@@H](CCCNC(=N)NC)C(=O)O.CC(=O)O -
由来
Synthetic
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研究分野
- Biochemicals
- Pharmacology
- Signaling
- Signal transduction
- Nitric oxide & oxidative stress
- NOS
- Inhibitors
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
- Biochemicals
- Research Area
- Diabetes
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
- Biochemicals
- Research Area
- Hypertension
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
- Biochemicals
- Research Area
- Obesity
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
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プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (8)
ab120137 は 8 報の論文で使用されています。
- Wong NF & Xu-Friedman MA Induction of Activity-Dependent Plasticity at Auditory Nerve Synapses. J Neurosci 42:6211-6220 (2022). PubMed: 35790402
- Ebner J et al. Neuronal nitric oxide synthase regulation of calcium cycling in ventricular cardiomyocytes is independent of Cav1.2 channel modulation under basal conditions. Pflugers Arch 472:61-74 (2020). PubMed: 31822999
- Roselló-Busquets C et al. Nystatin Regulates Axonal Extension and Regeneration by Modifying the Levels of Nitric Oxide. Front Mol Neurosci 13:56 (2020). PubMed: 32317932
- Devarakonda CV et al. CD13 deficiency leads to increased oxidative stress and larger atherosclerotic lesions. Atherosclerosis 287:70-80 (2019). PubMed: 31229835
- Lim SY et al. A New Neolignan Derivative, Balanophonin Isolated from Firmiana simplex Delays the Progress of Neuronal Cell Death by Inhibiting Microglial Activation. Biomol Ther (Seoul) 25:519-527 (2017). PubMed: 28554197
- Lood C et al. Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease. Nat Med N/A:N/A (2016). PubMed: 26779811
- Liu G et al. Targeting S1P1 receptor protects against murine immunological hepatic injury through myeloid-derived suppressor cells. J Immunol 192:3068-79 (2014). PubMed: 24567529
- Liu X et al. Calcium channels in rat horizontal cells regulate feedback inhibition of photoreceptors through an unconventional GABA- and pH-sensitive mechanism. J Physiol 591:3309-24 (2013). PubMed: 23613534