製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 配列A 16 amino acid synthetic peptide whose sequences are derived from amino acids 887-902 of human Maxi K+ alpha protein: R(887)DLSGFPAPPGEEPPA(902).
    • 領域887 to 902

関連製品

特性

Our Abpromise guarantee covers the use of ab4979 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Neutralising

    Blocking - Blocking peptide for Anti-NFATC4 antibody (ab3447)

  • 製品の状態Liquid
  • 備考

    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human NFAT 3, catalog ab3447. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

関連情報

  • 別名
    • cytoplasmic 4
    • NF ATc4
    • NF-AT3
    • NF-ATc4
    • NFAC4_HUMAN
    • NFAT3
    • NFATc4
    • Nuclear factor of activated T cells cytoplasmic 4
    • Nuclear factor of activated T cells cytoplasmic calcineurin dependent 4
    • Nuclear factor of activated T-cells
    • T cell transcription factor NFAT3
    • T-cell transcription factor NFAT3
    see all
  • 機能Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL-4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons.
  • 組織特異性Highly expressed in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and thymus. Not expressed in peripheral blood lymphocytes. Detected in hippocampus.
  • 配列類似性Contains 1 IPT/TIG domain.
    Contains 1 RHD (Rel-like) domain.
  • ドメインRel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors.
  • 翻訳後修飾Phosphorylated by NFATC-kinases; dephosphorylated by calcineurin. Phosphorylated on Ser-168 and Ser-170 by MTOR, IRAK1, MAPK7 and MAPK14, on Ser-213 and Ser-217 by MAPK8 and MAPK9, and on Ser-289 and Ser-344 by RPS6KA3. Phosphorylated by GSK3B.
    Ubiquitinated, leading to its degradation by the proteasome and reduced transcriptional activity. Ubiquitination and reduction in transcriptional activity can be further facilitated through GSK3B-dependent phosphorylation. Polyubiquitin linkage is mainly through 'Lys-48'.
  • 細胞内局在Cytoplasm. Nucleus. Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
  • Information by UniProt

NFATC4 peptide (ab4979) 使用論文

ab4979 has not yet been referenced specifically in any publications.

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