製品の概要

  • 製品名
    NF023
  • 製品の詳細
    Competitive P2X1 receptor antagonist
  • 生理活性の詳細
    Suramin analog and subtype-selective competitive antagonist at P2X1 receptors (IC50 values are 0.21, 28.9, >50 and >100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses, respectively). Inhibits contraction induced by electrical field stimulation in smooth muscle.
  • 精製度
    > 96%

製品の特性

  • 体系名
    8,8'-[Carbonylbis(imino-3,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt
  • 分子量
    1162.86
  • 構造式
    Chemical Structure
  • 分子式
    C35H20N4Na6O21S6
  • CAS 番号
    104869-31-0
  • PubChem 登録番号
    4465
  • 保存方法
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解性
    Soluble in water to 100 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記
    O=S(=O)(O[Na])c1cc(cc2c1c(ccc2S(=O)(=O)O[Na])NC(=O)c3cc(ccc3)NC(=O)Nc4cccc(c4)C(=O)Nc6ccc(c5cc(cc(c56)S(=O)(=O)O[Na])S(=O)(=O)O[Na])S(=O)(=O)O[Na])S(=O)(=O)O[Na]
  • 由来

    Synthetic

  • 研究分野

参考文献

This product has been referenced in:
  • Cho YR  et al. P2X and P2Y Receptors Mediate Contraction Induced by Electrical Field Stimulation in Feline Esophageal Smooth Muscle. Korean J Physiol Pharmacol 14:311-6 (2010). Read more (PubMed: 21165330) »
  • Soto F  et al. Antagonistic properties of the suramin analogue NF023 at heterologously expressed P2X receptors. Neuropharmacology 38:141-9 (1999). Read more (PubMed: 10193905) »
  • Ralevic V & Burnstock G Receptors for purines and pyrimidines. Pharmacol Rev 50:413-92 (1998). Read more (PubMed: 9755289) »

See 0 Publications for this product

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