製品の概要

  • 製品名NF 449
  • 製品の詳細
    Highly selective, potent P2X1 receptor antagonist
  • 生理活性の詳細Highly selective, potent hP2X1 receptor antagonist (IC50 values are 0.05 nM (hP2X1), 40 μM (hP2X7), 0.28 (rP2X1), 0.69 (rP2X1/5), 120 (rP2X2/3), 1820 (rP2X3), 47000 (rP2X2) and >300000 nM (P2X4)). Suramin (ab120422) analog. Reduces collagen induced platelet aggregation and inhibits calcium influx.
  • 精製度> 95%

製品の特性

  • 体系名4,4',4'',4'''-[Carbonylbis(imino-5,1,3-benzenetriyl-bis(carbonylimino))]tetrakis-1,3-benzenedisulfonic acid octasodium salt
  • 分子量1505.06
  • 構造式Chemical Structure
  • 分子式C41H24N6Na8O29S8
  • CAS 番号389142-38-5
  • PubChem 登録番号4469
  • 保存方法Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解性Soluble in water to 50 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記O=S(=O)(O[Na])c6ccc(NC(=O)c1cc(cc(c1)C(=O)Nc2ccc(cc2S(=O)(=O)O[Na])S(=O)(=O)O[Na])NC(=O)Nc3cc(cc(c3)C(=O)Nc4ccc(cc4S(=O)(=O)O[Na])S(=O)(=O)O[Na])C(=O)Nc5ccc(cc5S(=O)(=O)O[Na])S(=O)(=O)O[Na])c(c6)S(=O)(=O)O[Na]
  • 由来

    Synthetic

  • 研究分野

    NF 449 (ab120415) 使用論文

    This product has been referenced in:
    • Rettinger J  et al. Profiling at recombinant homomeric and heteromeric rat P2X receptors identifies the suramin analogue NF449 as a highly potent P2X1 receptor antagonist. Neuropharmacology 48:461-8 (2005). Read more (PubMed: 15721178) »
    • Hechler B  et al. Inhibition of platelet functions and thrombosis through selective or nonselective inhibition of the platelet P2 receptors with increasing doses of NF449 [4,4',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis-(carbonylimino)))tetrakis-benzene-1,3-disulfonic acid octasodium salt]. J Pharmacol Exp Ther 314:232-43 (2005). Read more (PubMed: 15792995) »
    • Hülsmann M  et al. NF449, a novel picomolar potency antagonist at human P2X1 receptors. Eur J Pharmacol 470:1-7 (2003). Read more (PubMed: 12787824) »

    See all 2 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"