製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to Neurturin
  • アプリケーション
    適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide, corresponding to amino acids 178-193 of Human Neurturin (Peptide available as ab8393.)

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファー
    PBS with 0.02% sodium azide
  • Concentration information loading...
  • 精製度
    IgG fraction
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab8061 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500. Detects a band of approximately 14 kDa.Can be blocked with Neurturin peptide (ab8393).
IHC-P Use a concentration of 5 µg/ml.

ターゲット情報

  • 機能
    Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.
  • 関連疾患
    Defects in NRTN are a cause of Hirschsprung disease (HSCR) [MIM:142623]. In association with mutations of RET gene, and possibly with other loci, defects in NRTN are involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.
  • 配列類似性
    Belongs to the TGF-beta family. GDNF subfamily.
  • 細胞内局在
    Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Neurturin antibody
    • Neurturin precursor antibody
    • NRTN antibody
    • NRTN_HUMAN antibody
    • NTN antibody
    • prepro-neurturin antibody
    see all

Anti-Neurturin antibody 画像

  • Immunohistochemistry (Formalin-fixed paraffin embedded sections) of human brain tissue labeling Neurturin with Anti-Neurturin antibody (ab8061) at 5μg/ml.
  • All lanes : Anti-Neurturin antibody (ab8061) at 1/500 dilution

    Lane 1 : 10ng full length recombinant Neurturin in HeLa cell lysate
    Lane 2 : 2.5ng full length recombinant Neurturin in HeLa cell lysate
  • ab8061 at 5µg/ml staining Neurturin in human brain tissue by IHC.

Anti-Neurturin antibody (ab8061) 使用論文

This product has been referenced in:
  • Samiotaki G  et al. Enhanced delivery and bioactivity of the neurturin neurotrophic factor through focused ultrasound-mediated blood--brain barrier opening in vivo. J Cereb Blood Flow Metab 35:611-22 (2015). Read more (PubMed: 25586140) »
  • Wang K  et al. The neurotrophic factor neurturin contributes toward an aggressive cancer cell phenotype, neuropathic pain and neuronal plasticity in pancreatic cancer. Carcinogenesis N/A:N/A (2013). IHC ; Human . Read more (PubMed: 24067900) »

See all 3 Publications for this product

Product Wall

Application
Western blot
Sample
Human Recombinant protein (Extracts of transfected hNRTN COS-1 cells)
Gel Running Conditions
Reduced Denaturing
Loading amount
15 µg
Specification
Extracts of transfected hNRTN COS-1 cells
Blocking step
Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 3% · Temperature: 25°C
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投稿 Aug 07 2015

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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