製品の概要

  • 製品名Anti-Neuroserpin antibody
    Neuroserpin 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to Neuroserpin
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant full length protein, corresponding to amino acids 17-411 of Human Neuroserpin

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab55587 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 46 kDa.
IHC-P Use a concentration of 3 µg/ml.

ターゲット情報

  • 機能Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.
  • 組織特異性Predominantly expressed in the brain.
  • 関連疾患Defects in SERPINI1 are the cause of familial encephalopathy with neuroserpin inclusion bodies (FEN1B) [MIM:604218]. FEN1B is characterized clinically as an autosomal dominantly inherited dementia, histologically by unique neuronal inclusion bodies and biochemically by polymers of neuroserpin.
  • 配列類似性Belongs to the serpin family.
  • 細胞内局在Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • DKFZp781N13156 antibody
    • Neuroserpin antibody
    • NEUS_HUMAN antibody
    • Peptidase inhibitor 12 antibody
    • PI-12 antibody
    • PI12 antibody
    • Protease inhibitor 12 antibody
    • Serine or cysteine proteinase inhibitor clade I (neuroserpin) member 1 antibody
    • Serine or cysteine proteinase inhibitor clade I member 1 antibody
    • Serpin I1 antibody
    • Serpin peptidase inhibitor clade I (neuroserpin) member 1 antibody
    • SERPINI1 antibody
    see all

Anti-Neuroserpin antibody 画像

  • Neuroserpin antibody (ab55587) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human cerebral cortex.


  • Predicted band size : 46 kDa
    Neuroserpin antibody (ab55587) at 1ug/lane + HeLa cell lysate at 25ug/lane.

Anti-Neuroserpin antibody (ab55587) 使用論文

This product has been referenced in:
  • Wong TH  et al. PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology. Brain 137:1361-73 (2014). Read more (PubMed: 24722252) »

See 1 Publication for this product

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample Human Tissue sections (Brain)
Specification Brain
Fixative Formaldehyde
Antigen retrieval step Heat mediated - Buffer/Enzyme Used: EDTA
Permeabilization No
Blocking step Serum as blocking agent for 20 minute(s) · Concentration: 10% · Temperature: RT°C
Username

Dr. Rachel Barker

Verified customer

投稿 Jan 07 2010

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Sample Human Tissue lysate - whole (Brain)
Loading amount 30 µg
Specification Brain
Treatment Homogenised in 1% SDS lysis buffer
Gel Running Conditions Reduced Denaturing (4-20% Tris-HCl gel)
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 10% · Temperature: RT°C
Username

Dr. Rachel Barker

Verified customer

投稿 Nov 30 2009

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"