Anti-Neurofilament heavy polypeptide 抗体 [RNF404] (ab8972)

製品の概要

  • 製品名
    Anti-Neurofilament heavy polypeptide antibody [RNF404]
    Neurofilament heavy polypeptide 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [RNF404] to Neurofilament heavy polypeptide
  • 特異性
    Reacts with the intermediate filament protein of periferal and central nerve cells, corresponding in Western blotting with the 200 kDa protein. Specific for the phosphorylated isoform.
  • アプリケーション
    適用あり: IHC-Fr, WB, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Rat, Sheep, Rabbit, Chicken, Guinea pig, Cow, Dog, Human, Xenopus laevis, Monkey
  • 免疫原

    Neurofilament preparation of calf brain tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab8972 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-Fr 1/50 - 1/100.
WB 1/100 - 1/500.
IHC-P 1/50 - 1/100.

ターゲット情報

  • 機能
    Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins.
  • 関連疾患
    Defects in NEFH are a cause of susceptibility to amyotrophic lateral sclerosis (ALS) [MIM:105400]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors.
  • 配列類似性
    Belongs to the intermediate filament family.
  • 翻訳後修飾
    There are a number of repeats of the tripeptide K-S-P, NFH is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFH results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber.
    Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincident with a change in the neurofilament function.
    Phosphorylated in the Head and Rod regions by the PKC kinase PKN1, leading to inhibit polymerization.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 200 kDa neurofilament protein antibody
    • CMT2CC antibody
    • Nefh antibody
    • Neurofilament heavy polypeptide 200kDa antibody
    • Neurofilament heavy polypeptide antibody
    • Neurofilament triplet H protein antibody
    • NF H antibody
    • NF-H antibody
    • NFH antibody
    • NFH_HUMAN antibody
    see all

Anti-Neurofilament heavy polypeptide antibody [RNF404] 画像

  • Immunohistochemistry on paraffin section of human heart

Anti-Neurofilament heavy polypeptide antibody [RNF404] (ab8972) 使用論文

ab8972 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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