製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to Neurexin 1
  • 特異性
    This antibody is expected to recognise both reported isoforms (NP_004792.1 and NP_620072.1).
  • アプリケーション
    適用あり: ELISA, WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Dog
  • 免疫原

    A synthetic peptide correspoding to a C terminal end of Neurexin 1 (Human)(NP_004792.1 , NP_620072.1)

  • ポジティブ・コントロール
    • Human brain (Cerebellum) lysates

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab79587 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA
WB
  • 追加情報
    ELISA: Use at an assay dependent dilution. Antibody detection limit in peptide ELISA assay: 1/32000.
    WB: Use at a concentration of 0.05 - 0.1 µg/ml. Predicted molecular weight: 162 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom.
    • 組織特異性
      Brain.
    • 配列類似性
      Belongs to the neurexin family.
      Contains 3 EGF-like domains.
      Contains 6 laminin G-like domains.
    • 翻訳後修飾
      N-glycosylated.
      O-glycosylated.
    • 細胞内局在
      Cell membrane. Cell junction, synapse. Localized on the pre-synaptic membrane.
    • Information by UniProt
    • 参照データベース
    • 製品の状態
      The neurexin genes use alternate promoters, splice sites and exons to encode potentially hundreds or thousands of mRNA transcripts.
    • 別名
      • DKFZp313P2036 antibody
      • FLJ35941 antibody
      • Hs.22998 antibody
      • KIAA0578 antibody
      • Neurexin 1 alpha antibody
      • Neurexin 1 beta antibody
      • Neurexin I-alpha antibody
      • Neurexin-1 antibody
      • Neurexin-1-alpha antibody
      • NRX1A_HUMAN antibody
      • NRXN1 antibody
      • PTHSL2 antibody
      • SCZD17 antibody
      see all

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    プロトコール

    参考文献

    ab79587 has not yet been referenced specifically in any publications.

    レビューと Q&A

    I have spoken with the lab regarding ab79587. We have not yet tested this product in ICC. For untested applications, we have established a testing discount program. Here is a brief description of how it works: The testing discount program is for...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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