Anti-Nesprin3 抗体 [Nsp3] (ab123031)
Key features and details
- Mouse monoclonal [Nsp3] to Nesprin3
- Suitable for: ICC/IF
- Reacts with: Mouse
- Isotype: IgG1
製品の概要
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製品名
Anti-Nesprin3 antibody [Nsp3]
Nesprin3 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [Nsp3] to Nesprin3 -
由来種
Mouse -
アプリケーション
適用あり: ICC/IFmore details -
種交差性
交差種: Mouse
非交差種: Human, Zebrafish -
免疫原
Recombinant fragment corresponding to Mouse Nesprin3. Fusion protein encoding the seventh spectrin repeat of Nesprin3 and a proprietary protein.
Database link: Q4FZC9 -
ポジティブ・コントロール
- Mouse embryonic fibroblasts.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
Preservative: 0.09% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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精製度
Protein G purified -
ポリ/モノ
モノクローナル -
クローン名
Nsp3 -
ミエローマ
Sp2/0 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab123031の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ICC/IF | (1) |
Use at an assay dependent concentration.
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特記事項 |
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ICC/IF
Use at an assay dependent concentration. |
ターゲット情報
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機能
Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. -
配列類似性
Belongs to the nesprin family.
Contains 1 KASH domain.
Contains 2 spectrin repeats. -
ドメイン
The KASH domain is involved in the binding to SUN1 and SUN2 through recognition of their SUN domains. -
細胞内局在
Nucleus outer membrane. Located at the rough reticulum endoplasmic (RER) in some cells. - Information by UniProt
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参照データベース
- Entrez Gene: 212073 Mouse
- SwissProt: Q4FZC9 Mouse
- Unigene: 212688 Mouse
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別名
- C14orf49 antibody
- Chromosome 14 open reading frame 49 antibody
- FLJ25605 antibody
see all
画像
データシートおよび資料
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Datasheet download
参考文献 (3)
ab123031 は 3 報の論文で使用されています。
- Pieuchot L et al. Curvotaxis directs cell migration through cell-scale curvature landscapes. Nat Commun 9:3995 (2018). PubMed: 30266986
- Alam SG et al. The mammalian LINC complex regulates genome transcriptional responses to substrate rigidity. Sci Rep 6:38063 (2016). ICC/IF . PubMed: 27905489
- Gutiérrez-Fernández A et al. Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid. EMBO J 34:1875-88 (2015). PubMed: 25991604