Anti-Nesprin3 抗体 (ab74261)
Key features and details
- Rabbit polyclonal to Nesprin3
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-Nesprin3 antibody
Nesprin3 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Nesprin3 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human -
免疫原
A synthesized peptide derived from an internal region of human Nesprin3.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, PBS
Stabilizing agent. -
Concentration information loading...
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精製度
Immunogen affinity purified -
特記事項(精製)
The antibody was affinity purified from rabbit antiserum by affinity chromatography using epitopespecific immunogen. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab74261の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/500 - 1/1000. Predicted molecular weight: 112 kDa.
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特記事項 |
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WB
1/500 - 1/1000. Predicted molecular weight: 112 kDa. |
ターゲット情報
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機能
Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. -
配列類似性
Belongs to the nesprin family.
Contains 1 KASH domain.
Contains 2 spectrin repeats. -
ドメイン
The KASH domain is involved in the binding to SUN1 and SUN2 through recognition of their SUN domains. -
細胞内局在
Nucleus outer membrane. Located at the rough reticulum endoplasmic (RER) in some cells. - Information by UniProt
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参照データベース
- Entrez Gene: 161176 Human
- Omim: 610861 Human
- SwissProt: Q6ZMZ3 Human
- Unigene: 354645 Human
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別名
- C14orf49 antibody
- Chromosome 14 open reading frame 49 antibody
- FLJ25605 antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (5)
ab74261 は 5 報の論文で使用されています。
- Lee HP et al. The nuclear piston activates mechanosensitive ion channels to generate cell migration paths in confining microenvironments. Sci Adv 7:N/A (2021). PubMed: 33523987
- Mayca Pozo F et al. MYO10 drives genomic instability and inflammation in cancer. Sci Adv 7:eabg6908 (2021). PubMed: 34524844
- Sun RC et al. Nuclear Glycogenolysis Modulates Histone Acetylation in Human Non-Small Cell Lung Cancers. Cell Metab 30:903-916.e7 (2019). PubMed: 31523006
- Ji Y et al. Sperm-associated antigen 4 (SPAG4) as a new cancer marker interacts with Nesprin3 to regulate cell migration in lung carcinoma. Oncol Rep 40:783-792 (2018). PubMed: 29901114
- Coffinier C et al. Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency. Proc Natl Acad Sci U S A 107:5076-81 (2010). WB, ICC/IF ; Mouse . PubMed: 20145110