製品の概要

  • 製品名Anti-Nephronophthisis antibody
    Nephronophthisis 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Nephronophthisis
  • アプリケーション適用あり: WB, IPmore details
  • 種交差性
    交差種: Mouse
  • 免疫原

    Fusion protein of a portion of mouse NPH corresponding to amino acid residues 612-691 (pic region).

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab11501 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 2 - 10 µg/ml. Detects a band of approximately 90 kDa.
IP Use a concentration of 2 - 10 µg/ml.

ターゲット情報

  • 関連性Juvenile nephronophthsis, an autosomal recessive cystic kidney disease, is the primary cause for chronic renal failure in children. The gene for nephronophthsis type 1 (NPHP1) has recently been identified. Nephronophthisis together with Cas it may play a role in the control of epithelial cell polarity. Seems to help to recruit protein tyrosine kinase 2 beta (PTK2B) to cell matrix adhesions, thereby initiating phosphorylation of PTK2B and PTK2B-dependent signaling . NPHP1 expression has been studied in mouse and human systems. Expression in the human adult is widespread but relatively weak. In contrast, expression in adult mouse is strong and localized to the testis. In situ hybridization to whole mouse embryo demonstrates widespread and consistently strong expression throughout all developmental stages. 4 isoforms exist, produced by alternative splicing.
  • 細胞内局在Cell junction, adherens junction. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Cell junction, tight junction.
  • 参照データベース
  • 別名
    • JBTS4 antibody
    • Juvenile nephronophthisis 1 protein antibody
    • Nephrocystin 1 antibody
    • nephronophthisis 1 (juvenile) antibody
    • Nephronophthisis antibody
    • NPH1 antibody
    • NPHP1 antibody
    • SLSN1 antibody
    see all

Anti-Nephronophthisis antibody (ab11501) 使用論文

This product has been referenced in:
  • Murga-Zamalloa CA  et al. Interaction of ciliary disease protein retinitis pigmentosa GTPase regulator with nephronophthisis-associated proteins in mammalian retinas. Mol Vis 16:1373-81 (2010). IP ; Mouse . Read more (PubMed: 20664800) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"