製品の概要

  • 製品名Anti-Nephrocystin 4 antibody
    Nephrocystin 4 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Nephrocystin 4
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide derived from an internal sequence from the Human Nephrocystin 4 protein (O75161).

  • ポジティブ・コントロール
    • human colon carcinoma tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab111408 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 組織特異性Expressed in kidney, skeletal muscle, heart and liver, and to a lesser extent in brain and lung.
  • 関連疾患Defects in NPHP4 are the cause of nephronophthisis type 4 (NPHP4) [MIM:606966]; also known as familial juvenile nephronophthisis 4. NPHP4 is an autosomal recessive inherited disease resulting in end-stage renal disease at age ranging between 6 and 35 years. It is a progressive tubulo-interstitial kidney disorder characterized by polydipsia, polyuria, anemia and growth retardation. The most prominent histological features are modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts.
    Defects in NPHP4 are the cause of Senior-Loken syndrome type 4 (SLSN4) [MIM:606996]. SLSN is a renal-retinal disorder characterized by progressive wasting of the filtering unit of the kidney, with or without medullary cystic renal disease, and progressive eye disease. Typically this disorder becomes apparent during the first year of life.
  • 配列類似性Belongs to the NPHP4 family.
  • 細胞内局在Cytoplasm > cytoskeleton > cilium basal body. Cytoplasm > cytoskeleton > centrosome.
  • Information by UniProt
  • 参照データベース
  • 別名
    • KIAA0673 antibody
    • Nephrocystin-4 antibody
    • nephronophthisis 4 antibody
    • Nephroretinin antibody
    • NPHP4 antibody
    • NPHP4_HUMAN antibody
    • POC10 antibody
    • POC10 centriolar protein homolog antibody
    • SLSN4 antibody
    see all

Anti-Nephrocystin 4 antibody 画像

  • Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using anti Nephrocystin 4 antibody (ab111408). The picture on the right is treated with the synthesized peptide.

Anti-Nephrocystin 4 antibody (ab111408) 使用論文

ab111408 has not yet been referenced specifically in any publications.

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