製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to NEIL2
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a sequence between N terminal amino acids 66-96 of Human NEIL2 (NP_001129220.1, NP_001129218.1, NP_659480.1).

  • ポジティブ・コントロール
    • HepG2 cell line lysates

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • バッファー
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • 特記事項(精製)
    ab124106 is purified through a protein A column, followed by peptide affinity purification.
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab124106 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 37 kDa.

ターゲット情報

  • 機能
    Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
  • 組織特異性
    Detected in testis, skeletal muscle, heart, brain, placenta, lung, pancreas, kidney and liver.
  • 配列類似性
    Belongs to the FPG family.
    Contains 1 FPG-type zinc finger.
  • ドメイン
    The zinc-finger domain is important for DNA binding.
  • 細胞内局在
    Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • DNA glycosylase/AP lyase Neil2 antibody
    • DNA-(apurinic or apyrimidinic site) lyase Neil2 antibody
    • Endonuclease 8-like 2 antibody
    • Endonuclease VIII-like 2 antibody
    • NEH2 antibody
    • Nei endonuclease VIII like 2 (E. coli) antibody
    • Nei endonuclease VIII like 2 antibody
    • Nei homolog 2 antibody
    • Nei-like 2 antibody
    • Nei-like protein 2 antibody
    • NEI2 antibody
    • NEIL2 antibody
    • NEIL2_HUMAN antibody
    see all

画像

  • Anti-NEIL2 antibody (ab124106) at 1/100 dilution + HepG2 cell line lysates at 35 µg

    Predicted band size : 37 kDa

プロトコール

参考文献

ab124106 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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