製品の概要

  • 製品名
    Nefazodone hydrochloride
  • 製品の詳細
    Potent 5-HT2A antagonist
  • 生理活性の詳細
    Potent 5-HT2A receptor antagonist (Ki = 7.1 nM for inhibition of [3H] ketanserin binding in rat cortex). Additionally blocks α1 adrenoceptors (Ki values are 5.5 and 84 nM at α1 and α2, respectively). Acts as a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) (Ki values are 220 and 555 nM at rat SERT and NET, respectively). Antidepressant.
  • 精製度
    > 99%

製品の特性

参考文献

This product has been referenced in:
  • Owens MJ  et al. Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J Pharmacol Exp Ther 283:1305-22 (1997). Read more (PubMed: 9400006) »
  • Taylor DP  et al. Pharmacology and neurochemistry of nefazodone, a novel antidepressant drug. J Clin Psychiatry 56 Suppl 6:3-11 (1995). Read more (PubMed: 7649970) »
  • Cusack B  et al. Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl) 114:559-65 (1994). Read more (PubMed: 7855217) »

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