製品の概要

製品の詳細

  • 由来Synthetic

関連製品

特性

Our Abpromise guarantee covers the use of ab4909 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 製品の状態Liquid
  • 備考


    This peptide may be used for neutralization and control experiments with the monoclonal antibody that reacts with this product and SMRT, catalog ab2780. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

関連情報

  • 別名
    • CTG 26
    • CTG repeat protein 26
    • CTG26
    • N CoR2
    • N-CoR2
    • NCoR 2
    • Ncor2
    • NCOR2_HUMAN
    • Nuclear Receptor Co-Repressor 2
    • Nuclear receptor corepressor 2
    • retinoic-acid-receptor-associated corepressor
    • Silencing Mediator for Retanoid and Thyroid Hormone Receptors
    • Silencing mediator of retinoic acid and thyroid hormone receptor
    • SMAP 270
    • SMAP270
    • SMRT
    • SMRTE
    • SMRTE tau
    • T3 receptor associating factor
    • T3 receptor-associating factor
    • Thyroid retinoic acid receptor associated corepressor
    • Thyroid-
    • TNRC 14
    • TNRC14
    • TRAC
    • TRAC 1
    • TRAC1
    see all
  • 機能Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors.
  • 組織特異性Ubiquitous. High levels of expression are detected in lung, spleen and brain.
  • 配列類似性Belongs to the N-CoR nuclear receptor corepressors family.
    Contains 2 SANT domains.
  • ドメインThe N-terminal region contains repression functions that are divided into three independent repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor-interacting domains that are divided in two separate interaction domains (ID1 and ID2).
    The two interaction domains (ID) contain a conserved sequence referred to as the CORNR box. This motif is required and sufficient to permit binding to unligated TR and RARS. Sequences flanking the CORNR box determine nuclear hormone receptor specificity.
  • 細胞内局在Nucleus.
  • Information by UniProt

NCOR2 peptide (ab4909) 使用論文

ab4909 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"