製品の概要

  • 製品名Anti-NCoR2 antibody
    NCOR2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to NCoR2
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide:

    PAPPAPPPPQNL

    , corresponding to amino acids 994-1005 of Human NCoR2

  • ポジティブ・コントロール
    • Human brain tissue and human lung carcinoma tissue.

アプリケーション

Our Abpromise guarantee covers the use of ab74518 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
  • 追加情報IHC-P: 1/25 for 10 minutes at room temperature.
    Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 minutes followed by cooling at room temperature for 20 minutes.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors.
    • 組織特異性Ubiquitous. High levels of expression are detected in lung, spleen and brain.
    • 配列類似性Belongs to the N-CoR nuclear receptor corepressors family.
      Contains 2 SANT domains.
    • ドメインThe N-terminal region contains repression functions that are divided into three independent repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor-interacting domains that are divided in two separate interaction domains (ID1 and ID2).
      The two interaction domains (ID) contain a conserved sequence referred to as the CORNR box. This motif is required and sufficient to permit binding to unligated TR and RARS. Sequences flanking the CORNR box determine nuclear hormone receptor specificity.
    • 細胞内局在Nucleus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • CTG 26 antibody
      • CTG repeat protein 26 antibody
      • CTG26 antibody
      • N CoR2 antibody
      • N-CoR2 antibody
      • NCoR 2 antibody
      • Ncor2 antibody
      • NCOR2_HUMAN antibody
      • Nuclear Receptor Co-Repressor 2 antibody
      • Nuclear receptor corepressor 2 antibody
      • retinoic-acid-receptor-associated corepressor antibody
      • Silencing Mediator for Retanoid and Thyroid Hormone Receptors antibody
      • Silencing mediator of retinoic acid and thyroid hormone receptor antibody
      • SMAP 270 antibody
      • SMAP270 antibody
      • SMRT antibody
      • SMRTE antibody
      • SMRTE tau antibody
      • T3 receptor associating factor antibody
      • T3 receptor-associating factor antibody
      • Thyroid retinoic acid receptor associated corepressor antibody
      • Thyroid- antibody
      • TNRC 14 antibody
      • TNRC14 antibody
      • TRAC 1 antibody
      • TRAC antibody
      • TRAC1 antibody
      see all

    Anti-NCoR2 antibody 画像

    • ab74518, at 1/25 dilution, staining NCoR2 in formalin fixed, paraffin embedded human brain tissue by Immunohistochemistry.

    Anti-NCoR2 antibody (ab74518) 使用論文

    ab74518 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab74518.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"