製品の概要

  • 製品名
    NCH 51
  • 製品の詳細
    Novel HDAC inhibitor
  • 別名
    • PTACH
  • 生理活性の詳細
    Novel HDAC inhibitor (IC50 values are 32, 48 and 41 nM at HDAC4, HDAC1 and HDAC6, respectively). Induces apoptosis and inhibits cell growth of various malignant cells and tumor cells lines (EC50 = 3.8 μM). Also reactivates latent HIV-1 gene expression.
  • 精製度
    > 99%

製品の特性

  • 体系名
    2-Methylpropanethioic acid S-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl] ester
  • 分子量
    390.56
  • 構造式
    Chemical Structure
  • 分子式
    C20H26N2O2S2
  • CAS 番号
    848354-66-5
  • PubChem 登録番号
    11395181
  • 保存方法
    Store at +4°C. The product can be stored for up to 12 months.
  • 溶解性
    Soluble in DMSO to 100 mM and in ethanol to 25 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記
    O=C(Nc1nc(cs1)c2ccccc2)CCCCCCSC(=O)C(C)C
  • 由来

    Synthetic

  • 研究分野

参考文献

This product has been referenced in:
  • Victoriano AF  et al. Novel histone deacetylase inhibitor NCH-51 activates latent HIV-1 gene expression. FEBS Lett 585:1103-11 (2011). Read more (PubMed: 21402072) »
  • Sanda T  et al. Proteome analyses of the growth inhibitory effects of NCH-51, a novel histone deacetylase inhibitor, on lymphoid malignant cells. Leukemia 21:2344-53 (2007). Read more (PubMed: 17690692) »
  • Suzuki T  et al. Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates. J Med Chem 48:1019-32 (2005). Read more (PubMed: 15715470) »

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