製品の概要

  • 製品名NCH 51
  • 製品の詳細
    Novel HDAC inhibitor
  • 別名
    • PTACH
  • 生理活性の詳細Novel HDAC inhibitor (IC50 values are 32, 48 and 41 nM at HDAC4, HDAC1 and HDAC6, respectively). Induces apoptosis and inhibits cell growth of various malignant cells and tumor cells lines (EC50 = 3.8 μM). Also reactivates latent HIV-1 gene expression.
  • 精製度> 99%

製品の特性

    NCH 51 (ab120949) 使用論文

    This product has been referenced in:
    • Victoriano AF  et al. Novel histone deacetylase inhibitor NCH-51 activates latent HIV-1 gene expression. FEBS Lett 585:1103-11 (2011). Read more (PubMed: 21402072) »
    • Sanda T  et al. Proteome analyses of the growth inhibitory effects of NCH-51, a novel histone deacetylase inhibitor, on lymphoid malignant cells. Leukemia 21:2344-53 (2007). Read more (PubMed: 17690692) »
    • Suzuki T  et al. Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates. J Med Chem 48:1019-32 (2005). Read more (PubMed: 15715470) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"