Anti-Nav1.8/SCN10A 抗体 (ab66743)
Key features and details
- Rabbit polyclonal to Nav1.8/SCN10A
- Suitable for: ICC
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-Nav1.8/SCN10A antibody
Nav1.8/SCN10A 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Nav1.8/SCN10A -
由来種
Rabbit -
アプリケーション
適用あり: ICCmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide corresponding to Nav1.8/SCN10A (C terminal).
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
Constituent: Whole serum -
Concentration information loading...
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精製度
Whole antiserum -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab66743の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ICC |
1/100 - 1/1000.
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特記事項 |
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ICC
1/100 - 1/1000. |
ターゲット情報
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機能
Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms. -
組織特異性
Expressed in the dorsal root ganglia and sciatic nerve. -
関連疾患
Episodic pain syndrome, familial, 2 -
配列類似性
Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily.
Contains 1 IQ domain. -
ドメイン
The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position. -
翻訳後修飾
Ubiquitinated by NEDD4L; which promotes its endocytosis.
Phosphorylation at Ser-1451 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents. -
細胞内局在
Cell membrane. It can be translocated to the cell membrane through association with S100A10. - Information by UniProt
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参照データベース
- Entrez Gene: 6336 Human
- Omim: 604427 Human
- SwissProt: Q9Y5Y9 Human
- Unigene: 250443 Human
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別名
- hPN3 antibody
- mPN3 antibody
- Peripheral nerve sodium channel 3 antibody
see all
画像
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (4)
ab66743 は 4 報の論文で使用されています。
- Hulme AJ et al. Molecular and Functional Characterization of Neurogenin-2 Induced Human Sensory Neurons. Front Cell Neurosci 14:600895 (2020). PubMed: 33362470
- Christidis N et al. Expression of 5-HT3 receptors and TTX resistant sodium channels (Na(V)1.8) on muscle nerve fibers in pain-free humans and patients with chronic myofascial temporomandibular disorders. J Headache Pain 15:63 (2014). PubMed: 25261281
- Cejudo-Roman A et al. The voltage-gated sodium channel nav1.8 is expressed in human sperm. PLoS One 8:e76084 (2013). Flow Cyt, ICC/IF ; Human . PubMed: 24086692
- Pinto FM et al. Molecular and functional characterization of voltage-gated sodium channels in human sperm. Reprod Biol Endocrinol 7:71 (2009). ICC/IF ; Human . PubMed: 19607678