製品の概要

製品の詳細

  • 由来
    Native
  • 由来
    Native
  • アミノ酸配列
    • 生物種
      Rat

特性

Our Abpromise guarantee covers the use of ab92813 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性
    Activity: 100% by definition (eluted from SBTI) 1 ug of plasmin corresponds to 0.024 CU or to 0.028 CTA-U.
  • アプリケーション

    SDS-PAGE

  • 精製度
    > 95 % SDS-PAGE.
    Prepared from plasminogen by activation with immobilized Human uPA.
  • 製品の状態
    Liquid
  • 備考
    Spectrophotometric Data: Ultraviolet: Absorbance (280nm) = 4.5 Epsilon 0.1% = 1.69 Active Concentration = 2.66 mg/mL
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 0.1M Sodium chloride, 0.1M HEPES, pH 7.4

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • Plasminogen
    • PLG
  • 関連性
    Plasmin is an enzyme formed in the circulating blood, and many other extracellular fluids, from the zymogen plasminogen. Plasminogen is a single-chain glycoprotein with 790 amino acid residues. Activation to the active form, plasmin, by urokinase involves cleavage at the arg-val bond between residues 560 and 561, resulting in the formation of the 2-chain plasmin molecule held together by 2 disulfide linkages. The heavier chain contains about 411 residues and the lighter chain about 233. The main function of plasmin is the digestion of fibrin in blood clots. Plasmin is a proteolytic enzyme with a specificity similar to that of trypsin. Like trypsin, plasmin belongs to the family of serine proteinases, in which the active site catalytic triad, his-57, asp-102, and ser-195 (chymotrypsin numbering), is situated in the light chain. Plasmin acts as a proteolytic factor in a variety of processes other than fibrinolysis; including embryonic development, tissue remodelling, tumour invasion and inflammation; in ovulation it weakens the walls of the Graafian follicle. A Deficiency of plasmin may lead to thrombosis, as clots are not degraded adequately.
  • 細胞内局在
    Secreted

画像

  • 10% SDS-PAGE analysis of ab92813
    Lane 1: ab92813 (3µg) Reduced
    Lane 2: ab92813 (3µg) + Antiplasmin (10µg) Reduced
    Lane 3: ab92813 (3µg) Non-reduced
    Lane 4: ab92813 (3µg) + Antiplasmin (10µg) Non-reduced
    Lane 5: Molecular weight markers

参考文献

ab92813 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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