The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Activity is measured in a Factor Xa clotting assay and/or chromogenic substrate assay.
備考 Thaw rapidly in a 37oC water bath without allowing protein to warm to 37oC and immediately cool on ice.
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 7.40 Constituents: 0.32% Tris HCl, 4.06% Sodium chloride
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Activated factor Xa heavy chain
Coagulation factor X
Stuart Prower factor
機能Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
組織特異性Plasma; synthesized in the liver.
配列類似性Belongs to the peptidase S1 family. Contains 2 EGF-like domains. Contains 1 Gla (gamma-carboxy-glutamate) domain. Contains 1 peptidase S1 domain.
翻訳後修飾The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium. N- and O-glycosylated. The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway). The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.