Anti-Natural Killer Cell 抗体 [ANK44] (ab36388)

製品の概要

  • 製品名Anti-Natural Killer Cell antibody [ANK44]
  • 製品の詳細
    Mouse monoclonal [ANK44] to Natural Killer Cell
  • 特異性ab36388 also binds to rat gamma-delta-TCR T cells. It does not bind to alpha-beta-TCR T cells or to B cells. The antigen recognized by ab36388 is highly expressed on rat NK cells after IL-2-activation. The antigen is not expressed by unstimulated NK cells.
  • アプリケーション適用あり: IHC-Fr, IP, Flow Cytmore details
  • 種交差性
    交差種: Rat
  • 免疫原

    Preparation of IL-2-activated cultured NK cells (Wag rats)

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファーPreservative: 0.05% Sodium Azide
    Constituents: Tissue culture supernatant
  • 精製度Tissue culture supernatant
  • ポリ/モノモノクローナル
  • クローン名ANK44
  • アイソタイプIgG1
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab36388 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-Fr Use at an assay dependent concentration.
IP Use at an assay dependent concentration.
Flow Cyt Use at an assay dependent concentration. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

ターゲット情報

  • 関連性Natural killer cells (NK) are a type of lymphocyte and a component of innate immune defense. They share a common progenitor with T cells and have been described as large, granular, bone-marrow derived lymphocytes. These cells do not destroy the attacking microorganisms directly; they attack infected cells and cells that appear that they might be cancer. NK cells are not phagocytic; they weaken the target cell's plasma membrane, causing water and ions to diffuse into the cell and expanding it. Under this large pressure, the target cell lyses. NK cells are characterised immunohistochemically by the presence of CD56 and the absence of CD3 on the cell membrane. NK cells are activated in response to interferons or macrophage-derived cytokines. They serve to contain virus infections while the adaptive immune response is generating antigen specific cytotoxic T cells that can clear the infection. Patients deficient in NK cells prove to be highly susceptible to early phases of herpes virus infection.
  • 別名
    • Large granular lymphocytes antibody
    • LGLs antibody
    • NK cells antibody

Anti-Natural Killer Cell antibody [ANK44] (ab36388) 使用論文

This product has been referenced in:
  • Giezeman-Smits KM  et al. Novel monoclonal antibodies against membrane structures that are preferentially expressed on IL-2-activated rat NK cells. J Leukoc Biol 63:209-15 (1998). Read more (PubMed: 9468279) »

See 1 Publication for this product

Product Wall

Following up my previous message, I found the original article describing the production and characterization of the natural killer cell antibody ab36388, clone ANK44. The paper suggests that the protein this antibody recognizes, or at least the epitop...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"