Anti-Natural Killer Cell Activation Structures 抗体 [ANK61] (ab36392)
製品の概要
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製品名Anti-Natural Killer Cell Activation Structures antibody [ANK61]
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製品の詳細Mouse monoclonal [ANK61] to Natural Killer Cell Activation Structures
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由来種Mouse
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特異性The antigen recognized by ab36392 is highly expressed on freshly isolated and cultured NK cells. The antibody also binds to rat alpha beta TCR T cells and at a low level to B cells.
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アプリケーション適用あり: Flow Cyt, IP, IHC-Fr, IHC-Pmore details
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種交差性交差種: Rat
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免疫原
Cell preparation of IL 2 activated cultured NK cells (Wag rats)
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特記事項
Triggering of the antigen by ab36392 antibody activates the lytic machinery of rat NK cells, but not of T cells.
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
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バッファーPreservative: 0.05% Sodium Azide
Constituents: Tissue culture supernatant -
精製度Tissue culture supernatant
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一次抗体 備考Triggering of the antigen by ab36392 antibody activates the lytic machinery of rat NK cells, but not of T cells.
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ポリ/モノモノクローナル
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クローン名ANK61
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アイソタイプIgG1
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研究分野
関連製品
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Compatible Secondaries
アプリケーション
Our Abpromise guarantee covers the use of ab36392 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
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| Flow Cyt | Use at an assay dependent concentration. ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
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| IP | Use at an assay dependent concentration. | |
| IHC-Fr | Use at an assay dependent concentration. Use at an assay dependent concentration. |
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| IHC-P | Use at an assay dependent concentration. Use at an assay dependent concentration. |
ターゲット情報
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関連性Natural killer cells (NK) are a type of lymphocyte and a component of innate immune defense. They share a common progenitor with T cells and have been described as large, granular, bone-marrow derived lymphocytes. These cells do not destroy the attacking microorganisms directly; they attack infected cells and cells that appear that they might be cancer. NK cells are not phagocytic; they weaken the target cell's plasma membrane, causing water and ions to diffuse into the cell and expanding it. Under this large pressure, the target cell lyses. NK cells are characterised immunohistochemically by the presence of CD56 and the absence of CD3 on the cell membrane. NK cells are activated in response to interferons or macrophage-derived cytokines. They serve to contain virus infections while the adaptive immune response is generating antigen specific cytotoxic T cells that can clear the infection. Patients deficient in NK cells prove to be highly susceptible to early phases of herpes virus infection.
参考文献
This product has been referenced in:
- Reyes L et al. Porphyromonas gingivalis and adverse pregnancy outcome. J Oral Microbiol 10:1374153 (2018). Read more (PubMed: 29291034) »
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"