製品の概要

製品の詳細

  • 由来Natural
  • 由来Native
  • アミノ酸配列
    • 生物種Human

特性

Our Abpromise guarantee covers the use of ab91031 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    ELISA

  • 精製度> 95 % SDS-PAGE.
    Native protein isolated from Human urine.
  • 製品の状態Lyophilised
  • 備考Product is not sterile. Please filter the product by an appropriate sterile filter before using it in the cell culture.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: ddH20

  • 再構成Add 200ul deionized water and let the lyophilized pellet dissolve completely.

関連情報

  • 別名
    • ADMCKD2
    • FJHN
    • HNFJ
    • HNFJ1
    • MCKD2
    • medullary cystic kidney disease 2 (autosomal dominant)
    • Tamm Horsfall glycoprotein
    • Tamm Horsfall urinary glycoprotein
    • Tamm-Horsfall urinary glycoprotein
    • THGP
    • THP
    • Umod
    • Urehd1
    • urehr4
    • UROM_HUMAN
    • Uromodulin
    • uromodulin (uromucoid, Tamm-Horsfall glycoprotein)
    • Uromodulin, secreted form
    see all
  • 機能Not known. May play a role in regulating the circulating activity of cytokines as it binds to IL-1, IL-2 and TNF with high affinity.
  • 組織特異性Synthesized by kidney. Most abundant protein in normal human urine.
  • 関連疾患Defects in UMOD are the cause of familial juvenile hyperuricemic nephropathy type 1 (HNFJ1) [MIM:162000]. HNFJ1 is a renal disease characterized by juvenil onset of hyperuricemia, polyuria, progressive renal failure, and gout. The disease is associated with interstitial pathological changes resulting in fibrosis.
    Defects in UMOD are the cause of medullary cystic kidney disease type 2 (MCKD2) [MIM:603860]. MCKD2 is a form of tubulointerstitial nephropathy characterized by formation of renal cysts at the corticomedullary junction. It is characterized by adult onset of impaired renal function and salt wasting resulting in end-stage renal failure by the sixth decade.
    Defects in UMOD are the cause of glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI) [MIM:609886]. GCKDHI is a renal disorder characterized by a cystic dilation of Bowman space, a collapse of glomerular tuft, and hyperuricemia due to low fractional excretion of uric acid and severe impairment of urine concentrating ability.
  • 配列類似性Contains 3 EGF-like domains.
    Contains 1 ZP domain.
  • 細胞内局在Cell membrane. Secreted. Secreted after cleavage in the urine.
  • Information by UniProt

Natural Human Uromucoid protein 画像

  • 12% SDS Page analysis of ab91031.
    1. M.W. marker: 14, 21, 31, 45, 66, 97 kDa
    2. 5ug ab91031, reduced and heated
    3. 5ug ab91031, native

Natural Human Uromucoid protein (ab91031) 使用論文

ab91031 has not yet been referenced specifically in any publications.

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